نتایج جستجو برای: inos

تعداد نتایج: 7055  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Pawel J Kolodziejski Mohammad B Rashid N Tony Eissa

Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of many diseases. iNOS is active only as a homodimer. Dimerization of iNOS represents a potentially critical target for therapeutic intervention. In this study, we show that intracellular iNOS forms dimers that are "undisruptable" by boiling, denaturants, or reducing agents. Undisruptable...

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006
Eun-Mi Park Sunghee Cho Kelly A Frys Sara B Glickstein Ping Zhou Josef Anrather Margaret E Ross Costantino Iadecola

Estrogens have antiinflammatory actions and protect the brain from ischemic injury. Cerebral ischemia is accompanied by an inflammatory reaction that contributes to the tissue damage, an effect mediated in part by toxic amounts of nitric oxide (NO) produced by the inducible isoform of NO synthase (iNOS). Therefore, estrogens may protect the female brain by modulating postischemic iNOS expressio...

Journal: :American journal of physiology. Renal physiology 2001
M Porst A Hartner H Krause K F Hilgers R Veelken

This study was designed to test the hypothesis that glomerular de novo expression of inducible nitric oxide synthase (iNOS) contributes to renal hemodynamic abnormalities in liver cirrhosis developed 3 wk after common bile duct ligature (CBDL). De novo expression of iNOS mRNA was detected by RT-PCR in RNA extracts from isolated CBDL rat glomeruli whereas no iNOS mRNA was found in control rat gl...

Journal: :Nucleic Acids Research 2005
Katrin Linker Andrea Pautz Marcel Fechir Thomas Hubrich Jobst Greeve Hartmut Kleinert

We purified the KH-type splicing regulatory protein (KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays. In DLD-1 cells overexpressing KSRP cytokine-induced iNOS expression was markedly reduced. In accordance, downregulation of KSRP expr...

2007
Qianhong Li Wei Tan Qinghui Ou Wen-Jian Wu Diana Sturza Chuanjue Cui Roberto Bolli

Background—Gene therapy with inducible nitric oxide synthase (iNOS) markedly reduces myocardial infarct size; this effect is associated with cyclooxygenase-2 (COX-2) upregulation and is ablated by COX-2 inhibitors. However, pharmacological inhibitors are limited by relative lack of specificity; furthermore, the mechanism whereby iNOS gene therapy upregulates COX-2 remains unknown. Accordingly, ...

2006
Ursula Mayr Yiping Zou Zhongyi Zhang Hermann Dietrich Yanhua Hu Qingbo Xu

Inducible NO synthase (iNOS) is expressed by macrophages and smooth muscle cells in atherosclerotic lesions. Previously, we have established a mouse model for vein graft arteriosclerosis by grafting autologous jugular veins or vena cava to carotid arteries. Using this model, we studied the role of iNOS in the development of vein graft arteriosclerosis in iNOS / mice. Four weeks after grafting, ...

Journal: :Molecular pharmacology 2002
Riku Korhonen Aleksi Lahti Mari Hämäläinen Hannu Kankaanranta Eeva Moilanen

Nitric oxide (NO) production through the inducible nitric-oxide synthase (iNOS) pathway is increased in inflammatory diseases and leads to cellular injury. Anti-inflammatory steroids inhibit the expression of various inflammatory genes, including iNOS. In the present study, we investigated the mechanism how dexamethasone decreased NO production in murine J774 macrophages. Dexamethasone (0.1-10 ...

Journal: :Circulation 2007
Qianhong Li Yiru Guo Wei Tan Qinghui Ou Wen-Jian Wu Diana Sturza Buddhadeb Dawn Greg Hunt Chuanjue Cui Roberto Bolli

BACKGROUND Gene therapy with inducible nitric oxide synthase (iNOS) markedly reduces myocardial infarct size; this effect is associated with cyclooxygenase-2 (COX-2) upregulation and is ablated by COX-2 inhibitors. However, pharmacological inhibitors are limited by relative lack of specificity; furthermore, the mechanism whereby iNOS gene therapy upregulates COX-2 remains unknown. Accordingly, ...

Journal: :JPEN. Journal of parenteral and enteral nutrition 2007
Kosuke Matsui Yusai Kawaguchi Takashi Ozaki Katsuji Tokuhara Hironori Tanaka Masaki Kaibori Yoichi Matsui Yasuo Kamiyama Koji Wakame Takehito Miura Mikio Nishizawa Tadayoshi Okumura

BACKGROUND Active hexose correlated compound (AHCC) is a "complex compound" containing polysaccharides. AHCC has been reported to improve the prognosis of postoperative hepatocellular carcinoma patients. However, the molecular mechanism of this improvement is not fully understood. In the diseased liver, nitric oxide (NO) generated by inducible nitric oxide synthase (iNOS) is considered to be a ...

Journal: :Gut 1998
G Kolios N Rooney C T Murphy D A Robertson J Westwick

BACKGROUND Nitric oxide (NO) synthesis and inducible nitric oxide synthase (iNOS) expression are increased in colonic biopsy specimens from patients with ulcerative colitis, but the cellular source of NO production is not known. AIMS To examine the distribution of iNOS in human colonic mucosa and to explore the ability of T lymphocyte derived cytokines to regulate iNOS expression and activity...

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