BACKGROUND Harmful medication errors, or preventable adverse drug events (ADEs), are a prominent quality and cost issue in healthcare. Injectable medications are important therapeutic agents, but they are associated with a greater potential for serious harm than oral medications. The national burden of preventable ADEs associated with inpatient injectable medications and the associated medical ...

UNLABELLED Clinicians have had concerns about particulate matter contamination of injectable drug products since the development of the earliest intravenous therapeutics. All parenteral products contain particulate matter, and particulate matter contamination still has the potential to cause harm to patients. With tens of millions of doses of injectable drug products administered in the United ...

BACKGROUND With the emergence of new laser and dermatologic procedures, the need for more effective topical anesthesia continues to grow. There are now several topical anesthetics that are being used prior to laser and surgical procedures. OBJECTIVE To compare the degree and duration of anesthesia produced by four commonly used topical anesthetics, we performed a prospective study investigati...

BACKGROUND KYBELLA, ATX-101, is an injectable form of sodium deoxycholic acid. It is currently the only Food and Drug Administration-approved injectable drug for the reduction of submental fat. OBJECTIVES A literature review and discussion of the treatment of submental fat. RESULTS KYBELLA is a well-tolerated alternative for the treatment of submental fat. CONCLUSIONS KYBELLA is a safe an...

Currently available local anesthetics have analgesic durations in humans generally less than Prolonged-duration local anesthetics will be useful. to the complexities that a case of strabismus may pertain to, it is worthwhile to get to know more about the This brief review -as its name implieddoes not attempt surgery -due to myotoxicity by local anesthetic agent(albeit rare),. This review draws ...

BACKGROUND Cardiac surgery is associated with some degree of myocardial injury. Preconditioning first described in 1986 was pharmacologic and non- pharmacologic. Among the long list of anesthetic drugs, isoflurane as an inhaling agent along with midazolam and propofol as injectable substances have been documented to confer some preconditioning effects on myocardium. OBJECTIVES In this study c...

BACKGROUND Since the introduction of cocaine in 1884, local anesthetics have been used as a mainstay of pain management. However, numerous studies over the past several decades have elucidated the supplemental role of local anesthetics as antimicrobial agents. In addition to their anesthetic properties, medications such as bupivacaine and lidocaine have been shown to exhibit bacteriostatic, bac...

BACKGROUND Injection of filler substances into the lips is painful, and many patients also find the injection of local or regional anesthesia into the lips painful. OBJECTIVE To develop a highly effective and painless form of anesthesia to facilitate injection of filler substances into the lips. METHODS Five percent lidocaine cream was applied simultaneously to the skin, vermilion, and muco...

BACKGROUND Oral contraceptives are known to influence the risk of cancers of the female reproductive system. Evidence regarding the relationship between injectable contraceptives and these cancers is limited, especially in black South Africans, among whom injectable contraceptives are used more commonly than oral contraceptives. METHODS AND FINDINGS We analysed data from a South African hospi...