objective: gelatinases are a large group of proteolytic enzymes that belong to the matrix metalloproteinases (mmps). mmps are a broad family of peptidases, which proteolyse the extracellular matrix and have an important role in inflammation. verapamil is a calcium channel blocker extensively used in the treatment of numerous cardiovascular diseases such as arrhythmia and hypertension. the anti-...

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

A lymphocyte blastogenesis inhibitory factor (LBIF) has been char acterized as an immunoregulatory molecule, especially on the T-lymphocyte proliferation. Using fast protein liquid chromatography-purified LBIF, we examined the effect of LBIF on the proliferation of various 18 tumor cell lines in vitro in comparison with those of interferon-a, interferon-7, tumor necrosis factor-a, transforming ...

This study aimed to evaluate the composition, antioxidant capacity and antibacterial effects of Pistacia atlantica subsp. kurdica (baneh) essential oil on some important bacteria in food safety. Essential oil was derived using hydro-distillation method of the baneh fruits. Essential oil composition was determined using gas chromatography–mass spectrometry. The 2,2′-azinobis-(3...

in order to find the plant extracts with antifungal activity, 18 plant species were screened. in this study, distilled water, methanol, chloroform, aceton and ethanol were employed to obtain crude extract from plant samples. the extracts were tested against sugar beet root rot agents, rhizoctonia solani and phytophthora drechsleri. the inhibitory effect of different extracts was investigated by...

over production of uric acid by xanthine oxidase (xo) causes gout. xo inhibitors for example allopurinol are the most important available anti gout drugs. medicinal herbs are available natural sources that may be useful for the treatment of gout. in this study the inhibitory activity of aqueous extracts of matricaria chamomilla l., hypericum perforatum l., fraxinus excelsior l., zea mays l., tr...

this is the first report about adverse inhibitory effect of v-guard and e-guard gasoline additives against soil beneficial streptomyces. v-guard and e-guard gasoline additives are anti valve seat recession agents used in unleaded gas for old car engines in iran. they contaminate soil and groundwater by fuel leaks and spills. streptomyces are of the major contributors to the biological buffering...

abstract kinetic properties of root of peroxidase of gundelia tournefortii investigated at different ph, temperature and different inhibitors. maximum activity of peroxidase achieved at ph 5.5-6 in according to type of substrate. activity of peroxidase increased at constant concentration of h2o2 and different concentration of guaiacol, catechol and pyrogallol. the maximum activity in presence o...