Purpose: To determine the effect of dexmedetomidine on sepsis-mediated acute kidney injury (SAKI) in rats.
 Methods: Twenty-four SD rats were randomly divided into blank untreated control group, model group given lipopolysaccharide at a dose 10 mg/kg, (Dex) and glycogen synthase kinase-3 beta (GSK-3β) inhibitor sb216763. In addition, Dex groups received same as group. There each Pathologic...

Purpose: To investigate the effect of miR-493-5p in lipopolysaccharide (LPS) -induced ATDC5 chondrogenic cells.
 Methods: The MTT assay was used to determine viability LPS-induced cells. ENCORI (starbase.sysu.edu.cn/) predict target miR-493-5p. Quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) expression controlled cells and treated with various combinations LPS, negat...

In this study we intended to perform in silico and vitro analysis of naturally derived flavonoid, hesperetin as a promising mammalian target rapamycin inhibitor. This features screening natural compound against FK506 binding proteins 12 domain by using Schrodinger glide based virtual further molecular dynamics simulation was done infer the stability complex formation. Mammalian co-crystallized ...

Acquired hemophilia A (AHA) is a rare bleeding disorder, caused by the development of autoantibodies (inhibitor) against endogenous clotting factor VIII (FVIII). common clinical manifestation subcutaneous bleeding, but soft tissue hematomas and excessive post-operative hemorrhages may also occur. diagnosis AHA made in patients presenting with an isolated prolonged activated partial thromboplast...