Compassion shown towards victims often decreases as the number of individuals in need of aid increases, identifiability of the victims decreases, and the proportion of victims helped shrinks. Such “compassion fade” may hamper individual-level and collective responses to pressing large-scale crises. To date, research on compassion fade has focused on humanitarian challenges; thus, it remains unk...

Affiliations: 1Institute of Complex Systems and Mathematical Biology, University of Aberdeen, United Kingdom; 2Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Ireland; 3School of Physics, University College Dublin, Dublin, Ireland; and 4Institute for Molecular Bioscience, Division of Cell Biology and Molecular Medicine, The Univers...

A significant number of human immunodeficiency virus (HIV) infections have become resistant to antiretroviral treatment, which means that there is a paramount need for novel drug targets to defeat the virus. Until recently, all HIV drugs inhibited HIV replication by mechanisms operating inside infected cells. In contrast, new antiretroviral drugs operate outside infected cells. Their mechanism ...

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

crude glycerol (cg) is an abundantly available and cheap by-product from biodiesel production. value-added applications for cg are highly wanted by industry and several processes such as the use of cg for enhanced oil recovery have been proposed. the aim of this study was to evaluate the sulfide production of sulfate-reducing bacteria (srb) indigenous to oil reservoirs using cg as substrate. th...

bilberry [vaccinium myrtillus linn. (ericaceae)] fruit (vmf) has been traditionally used for treatment of bladder stones, biliary disorders, scurvy, coughs, and lung tuberculosis. vmf may have some pharmaceutical properties owing to these uses, but in vivo and in vitro studies are limited for clarification of medicinal activity and its antidiabetic and antioxidant properties are not investigate...

the effect of physiological concentrations of caffeine (purified from persian tea) on adenosine deaminase (ada) activity at physiological and pathological concentrations of adenosine (as substrate) in 50 mm tris-hcl buffer (ph 7.3) at 37°c was investigated, using uv-vis spectroscopy. ada exhibited a bi-phasic activity behavior and both phases showed positive cooperativities indicating adenosine...