نتایج جستجو برای: influenza antigen

تعداد نتایج: 267019  

2013
Matthias Mehling Stefanie Fritz Patricia Hafner Dominik Eichin Tomomi Yonekawa Thomas Klimkait Raija L. P. Lindberg Ludwig Kappos Christoph Hess

BACKGROUND Interferon-beta (IFNβ) regulates the expression of a complex set of pro- as well as anti-inflammatory genes. In cohorts of MS patients unstratified for therapeutic response to IFNβ, normal vaccine-specific immune responses have been observed. Data capturing antigen-specific immune responses in cohorts of subjects defined by response to IFNβ-therapy are not available. OBJECTIVE To a...

2012
Maria del Pilar Martin William C. Weldon Vladimir G. Zarnitsyn Dimitrios G. Koutsonanos Hamed Akbari Ioanna Skountzou Joshy Jacob Mark R. Prausnitz Richard W. Compans

UNLABELLED Microneedle patches (MN) provide a novel method of vaccine delivery to the skin with the objective of targeting the large network of resident antigen-presenting cells to induce an efficient immune response. Our previous reports demonstrated that cutaneous delivery of inactivated influenza virus-coated MN to mice protects against lethal infection. Protection is correlated with sustain...

Jafar Soltani, Mohamad Jamil Amjadi

We studied the safety of a trivalent inactivated surface antigen (split virion, inactivated) influenza vaccine, Begrivac® (Novartis Company), widely used in health care workers in Kurdistan. A longitudinal follow-up study was performed in Sanandaj city, west of Iran, recruiting 936 people. A questionnaire was completed for each participant, and all symptoms or abnormal physical findings were re...

2008
Melanie Saville Grenville Marsh Agnes Hoffenbach

Challenges facing seasonal and pandemic influenza vaccination include: increasing the immunogenicity of seasonal vaccines for the most vulnerable, increasing vaccination coverage against seasonal influenza, and developing vaccines against pandemic strains that are immunogenic with very low quantities of antigen to maximize the number of people who can be vaccinated with a finite production capa...

Journal: :Circulation 2012
Jennie Johnstone Mark Loeb Koon K Teo Peggy Gao Leanne Dyal Lisheng Liu Alvaro Avezum Ernesto Cardona-Munoz Peter Sleight Robert Fagard Salim Yusuf

BACKGROUND We sought to determine the association between influenza vaccination and major adverse vascular events because the association remains uncertain. METHODS AND RESULTS A total of 31 546 participants were enrolled from 40 countries. Eligibility included age ≥55 years and known vascular disease. The primary outcome was a composite of death resulting from cardiovascular causes, myocardi...

2010
Julia Steitz Peter G. Barlow Jaber Hossain Eun Kim Kaori Okada Tom Kenniston Sheri Rea Ruben O. Donis Andrea Gambotto

BACKGROUND In 2009 a new pandemic disease appeared and spread globally. The recent emergence of the pandemic influenza virus H1N1 first isolated in Mexico and USA raised concerns about vaccine availability. We here report our development of an adenovirus-based influenza H1N1 vaccine tested for immunogenicity and efficacy to confer protection in animal model. METHODS We generated two adenoviru...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2009
Christine C Ginocchio Frank Zhang Ryhana Manji Suman Arora Mark Bornfreund Leon Falk Madhavi Lotlikar Margaret Kowerska George Becker Diamanto Korologos Marcella de Geronimo James M Crawford

BACKGROUND In response to the novel influenza A H1N1 outbreak in the NY City area, 6090 patient samples were submitted over a 5-week period for a total of 14,114 viral diagnostic tests, including rapid antigen, direct immunofluorescence (DFA), viral culture and PCR. Little was known about the performance of the assays for the detection of novel H1N1 in the background of seasonal H1N1, H3N2 and ...

Journal: :Journal of virology 2015
Stefan J Halbherr Thomas H Ludersdorfer Meret Ricklin Samira Locher Marianne Berger Rentsch Artur Summerfield Gert Zimmer

UNLABELLED The envelope of influenza A viruses contains two large antigens, hemagglutinin (HA) and neuraminidase (NA). Conventional influenza virus vaccines induce neutralizing antibodies that are predominantly directed to the HA globular head, a domain that is subject to extensive antigenic drift. Antibodies directed to NA are induced at much lower levels, probably as a consequence of the immu...

Journal: :Pediatrics 2004
Stephen M Maricich Jeffrey L Neul Timothy E Lotze Andreea C Cazacu Timothy M Uyeki Gail J Demmler Gary D Clark

OBJECTIVES Our objectives were to (1) describe the clinical characteristics of and viruses isolated from patients who presented with neurologic symptoms associated with influenza A infection and were hospitalized at Texas Children's Hospital during October and November 2003 and (2) to raise awareness of the neurologic complications of influenza among US children. METHODS We reviewed the medic...

Journal: :Acta biochimica Polonica 2014
Karolina Uranowska Jolanta Tyborowska Anna Jurek Bogusław Szewczyk Beata Gromadzka

Influenza A virus infections are the major public health concern and cause significant morbidity and mortality each year worldwide. Vaccination is the main strategy of influenza epidemic prevention. However, seasonal vaccines induce strain-specific immunity and must be reformulated annually based on prediction of the strains that will circulate in the next season. Thus, it is essential to devel...

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