background inflammatory bowel diseases (ibd) are debilitating diseases that lead to a variety of problems in a patient's daily life and are a huge burden for the health care system. since this group of diseases are multifactorial and complex, long-term longitudinal studies are clearly needed to understand them better. a population-based registry (ibd-far) has been established in fars, a souther...

Background:
 Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Pathogenic T cells, such as Th1 and Th17, infiltrate CNS, resulting in neuroinflammation, demyelination axonal damage. activates microglia (MG) CNS Th17 acts a chemokine to recruit immune cells into CNS. MG resident cell its activation associated with destruction myelin secretion inflammatory...

microglia is the effector cell of the innate immune system in central nervous system (cns). these cells mediate inflammatory responses in injuries. besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. mechanisms of epigenetic regulation mainly consist of dna methylation, histone modifications and use of non-coding rnas. recent s...

The protein tyrosine phosphatase SHP-1 is a crucial negative regulator of cytokine signaling and inflammatory gene expression, both in the immune system and in the central nervous system (CNS). Mice genetically lacking SHP-1 (me/me) display severe inflammatory demyelinating disease following inoculation with the Theiler's murine encephalomyelitis virus (TMEV) compared to infected wild-type mice...

Multiple sclerosis (MS) is a chronic disease of the central nerve system (CNS) primarily affecting youngsters. The CNS has a potent antioxidant defense mechanism to scavenge reactive oxygen species (ROS). MS can be effectively studied in animal models with experimental autoimmune encephalomyelitis (EAE). The immunopathogenic mechanisms involved in EAE are attributed to T-cell-mediated inflammat...

Obesity is now recognized as a global health problem and has reached epidemic proportions, affecting both developed developing countries. This condition associated with an increased incidence in central nervous system (CNS) disorders. The intake of foods or supplements anti-inflammatory activity could potentially lead to lower impact obesity on the functionality CNS. Therefore, this work we tes...

Air pollution has been implicated as a chronic source of neuroinflammation and reactive oxygen species (ROS) that produce neuropathology and central nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's disease pathology are linked to air pollution. Recent reports reveal that air pollution components reach the brain; systemic effects that impact lung and cardiovascular ...

Nowadays, air pollution is one of the major problems in developed and developing countries. In recent years, effects of air pollution on neuroinflammatory diseases such as Alzheimer disease and Parkinson disease have been studied. Researches on polluted cities citizens indicate increasing in central nervous system (CNS) inflammatory factors in comparison with clean cities; also air pollution ex...

Natural killer (NK) cells of the innate immune system can profoundly impact the development of adaptive immune responses. Inflammatory and autoimmune responses in anatomical locations such as the central nervous system (CNS) differ substantially from those found in peripheral organs. We show in a mouse model of multiple sclerosis that NK cell enrichment results in disease amelioration, whereas ...

Multiple sclerosis is an inflammatory autoimmune-mediated disease of the Central Nervous System (CNS). Different treatment protocols, based on neurotropic viral infections and/or immunization with CNS proteins, have been implemented. Although there are encouraging outcomes, cure is still far from reach. Here, we discuss some of these treatment options.