نتایج جستجو برای: inflammasome

تعداد نتایج: 6318  

2017
Huihui Qian Qinghe Li Woda Shi

Growing evidence has demonstrated that the nucleotide‑binding oligomerization domain‑like receptor family pyrin domain containing 3 (NLRP‑3) inflammasome‑mediated inflammatory pathways have been involved in the secondary injury of traumatic brain injury (TBI). In the present study, the authors investigated the effects of hyperbaric oxygen (HBO) therapy on the NLRP‑3 inflammasome pathway followi...

2014
Deborah D. Crane Timothy J. Bauler Tara D. Wehrly Catharine M. Bosio

Activation of the inflammasome is important for the detection and clearance of cytosolic pathogens. In contrast to avirulent Francisella novicida (Fn), infection with virulent Francisella tularensis ssp tularensis does not trigger activation of the host AIM2 inflammasome. Here we show that differential activation of AIM2 following Francisella infection is due to sensitivity of each isolate to r...

Journal: :Journal of immunology 2012
Franz Bauernfeind Anna Rieger Frank A Schildberg Percy A Knolle Jonathan L Schmid-Burgk Veit Hornung

Inflammasomes are multiprotein signaling platforms that form upon sensing microbe- or damage-associated molecular patterns. Upon their formation, caspase-1 is activated, leading to the processing of certain proinflammatory cytokines and the initiation of a special type of cell death, known as pyroptosis. Among known inflammasomes, NLRP3 takes on special importance because it appears to be a gen...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Gimena dos Santos Mikhail A Kutuzov Karen M Ridge

Inflammation, the process aimed at restoring homeostasis after an insult, can be more damaging than the insult itself if uncontrolled, excessive, or prolonged. The inflammasome is an intracellular multimeric protein complex that regulates the maturation and release of proinflammatory cytokines of the IL-1 family in response to pathogens and endogenous danger signals. Growing evidence indicates ...

Journal: :AIMS mathematics 2021

Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases coronavirus disease 2019 (COVID-19). The formation NLRP3 inflammasome central pyroptosis, which may be induced by acute respiratory syndrome 2 (SARS-CoV-2). Inflammasome formation, and extension inhibited certain anti-inflammatory drugs. In this study, we present a ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Makoto Inoue Kristi L Williams Michael D Gunn Mari L Shinohara

The NLRP3 inflammasome is a multiprotein complex consisting of three kinds of proteins, NLRP3, ASC, and pro-caspase-1, and plays a role in sensing pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is thought to be involved in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, the mechanism by wh...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
John-Demian Sauer Sabine Pereyre Kristina A Archer Thomas P Burke Bill Hanson Peter Lauer Daniel A Portnoy

Inflammasomes are intracellular multiprotein signaling complexes that activate Caspase-1, leading to the cleavage and secretion of IL-1β and IL-18, and ultimately host cell death. Inflammasome activation is a common cellular response to infection; however, the consequences of inflammasome activation during acute infection and in the development of long-term protective immunity is not well under...

2017
Xia Zhao Chen Zhang Mingqiang Hua Ruiqing Wang Chaoqin Zhong Jie Yu Fengjiao Han Na He Yanan Zhao Guoqiang Liu Ni Zheng Chunyan Ji Daoxin Ma

Inflammasomes play important roles in the pathogenesis of tumors, but the roles of NLRP3 inflammasome in the lymphoma remain unclear. Activated NLRP3 inflammasome induces the maturation of its effector cytokine IL-18 which functions in the development of cancer. Here, we investigated the polymorphism and expression of NLRP3 inflammasome related genes and explored their function in lymphoma. We ...

Journal: :Scientific reports 2016
Evgenii Boriushkin Joshua J Wang Junhua Li Maulasri Bhatta Sarah X Zhang

The NLRP3 inflammasome activation is a key signaling event for activation and secretion of pro-inflammatory cytokines such as IL-1β from macrophages. p58(IPK) is a molecular chaperone that regulates protein homeostasis through inhibiting eIF-2α kinases including double-stranded RNA-dependent protein kinase (PKR), which has been recently implicated in inflammasome activation. Herein we investiga...

2017
Byung-Cheol Han Huijeong Ahn Jiseon Lee Eunsaem Jeon Sanghoon Seo Kyoung Hwa Jang Seung-Ho Lee Cheon Ho Kim Geun-Shik Lee

BACKGROUND Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. METHODS To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first...

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