(IAH) may have catas tro-phic eff ects on critically ill patients, but its patho physiology is only partially understood [1]. Oliguria and renal dysfunction are among the earliest signs of increasing intra-abdominal pressure (IAP) [2]. A number of diff erent pathophysiological mechanisms may be responsible [1]. One of these may be an increase in pro-infl ammatory cytokines provoked by IAH [2]. ...

Dear Editor, Acute disseminated encephalomyelitis (ADEM) is an immune-mediated infl ammatory disorder of the central nervous system. It has a monophasic course which occurs after viral infection or vaccination.1,2Acute haemorrhagic leucoencephalitis (AHLE) is considered to be a hyperacute form of ADEM which is fulminant and is frequently fatal.3 There are only a few cases of biopsy-proven AHLE ...

read with great interest the study by Engvall and colleagues [1] in a recent issue of Arthritis Research & Th erapy. Th e study showed that anti-tumor necrosis factor-alpha (anti-TNF-α) infl iximab therapy is associated with an increase of body fat mass in early rheumatoid arthritis (RA) independently of changes in disease activity and levels of leptin and adiponectin. With respect to this, we ...

e view of osteoarthritis (OA) as strictly a non-infl am-ma tory joint disease has evolved as imaging and histo-pathological studies have demonstrated that synovial infl ammation is present in many patients, and importantly , is associated with increased pain, poorer joint function , and accelerated deterioration of joint struc tures. In the current article by Sohn and colleagues [1], the author...

Address to: Dr. Dennis de Carvalho Ferreira. Programa de Mestrado em Odontologia/Universidade Veiga de Almeida. Rua Ibituruna 108, Maracanã, 20271-020 Rio de Janeiro, RJ, Brasil. Phone: 55 21 2574-8888 e-mail: [email protected] Received 8 April 2014 Accepted 14 May 2014 The challenge to diagnose a clinical case of infl ammatory linear verrucous epidermal nevus: Is there any ILVEN associated wi...

Acute disseminated encephalomyelitis (ADEM) is a monophasic, postinfectious or postvaccineal acute infl ammatory demyelinating disorder of central nervous system (CNS).[1,2] The pathophysiology involves transient autoimmune response directed at myelin or other self-antigens, possibly by molecular mimicry or by nonspecifi c activation of autoreactive T-cell clones.[3] Histologically, ADEM is cha...

Journal of Lipid Research Volume 55, 2014 2073 Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. Human apoE is present on nearly all serum lipoproteins and plays a protective role in atherosclerosis by acting both as a ligand for receptor-mediated lipoprotein clearance and as an acceptor for cholesterol exported by peripheral cells ( 1, 2 ). apoE on triglycer...

Th e term ‘idiopathic infl ammatory myopathy’ (IIM) usually refers to one of three related diseases: poly myositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM). Each variation of the disease has defi ning characteristics (for example, the heliotrope rash of DM or the intramuscular rimmed vacuoles of IBM), but there are some common characteristics. In PM and DM, patients typical...

Adipue and colleagues [1] have characterized the novel IIJ (inherited infl amed joints) mouse strain, a new murine model of infl ammatory, possibly autoimmune, arthritis that is similar both histologically and serologically to human rheumatoid arthritis (RA) and other murine models of autoimmune arthritis [1]. RA is a chronic and progressive infl ammatory disorder characterized by synovitis and...

© 2004 Blackwell Publishing Ltd the second most common cause of death in HIV infection after tuberculosis (French et al. 2002). Moreover, despite the availability of highly active antiretroviral therapy (HAART), it continues to pose diffi cult management questions in the industrialized world. Questions remain for physicians regarding the optimal combination of antifungal agents, duration of tre...