Wound infection is a common risk for patients with chronic nonhealing wounds, causing high morbidity and mortality. Currently, systemic antibiotic treatment is the therapy of choice, despite often leading to several side effects and the risk of an insufficient tissue penetration due to impaired blood supply. If systemically delivered, moxifloxacin penetrates well into inflammatory blister fluid...

BACKGROUND Cervical necrotizing fasciitis is an aggressive infection that can be rapidly fatal if aggressive therapies are not initiated early. Negative pressure wound therapy has been established as an effective tool in promoting wound healing, but its use in the acutely infected wound has been avoided because it limits frequent irrigations and standard dressing changes. METHODS We discuss a...

OBJECTIVE This paper presents a novel wound healing protocol for the treatment of MRSA-infected lower extremity wounds of various etiologies, and describes the healing rate at 30, 60 and 90 days. METHOD A total of 40 participants with singular wounds were enrolled and treated with a specially designed protocol, which involves elements of the de-escalation theory together with a wound dress co...

Abstract Nowadays, multidrug-resistant (MDR) bacterial infectious diseases has become a thorny issue in the healthcare field. Owning to its intrinsic merits, photodynamic therapy (PDT) shows tremendous strengths fighting against MDR infections. However, most nanoplatforms exhibit unsatisfactory targeting efficiency towards bacteria and infection site, which may compromise bactericidal effect of...

Advanced Medical Technology Association. 2006. Advanced wound management: Healing and restoring lives. Efficacy of micronized flavonoid fraction in healing of clean and infected wounds.

One critical element for applying atmospheric pressure plasma jet medical purposes is that it possible to construct a combinatorial therapeutic regimen based on contact and noncontact styles the cold jet. This study evaluates effectiveness bacteria-infected wounds in small animal model. In this investigation, we test novel combinative treatment using style was generated at high voltage of ~ 9 k...

Honey has been described in ancient and modern medicine as being effective in the healing of various infected wounds. In this report we present our experience in nine infants with large, open, infected wounds that failed to heal with conventional treatment. Conventional treatment was defined as having failed if after > or = 14 d of intravenous antibiotic and cleaning the wound with chlorhexidin...

An animal model of wound botulism was developed in mice using an inoculum of Clostridium botulinum type A spores. The number of C. botulinum in infected wounds was quantitated by culturing on egg yolk agar, and the level of C. botulinum toxin in infected wound tissue was measured by a bioassay in mice and by an enzyme-linked immunosorbent assay. All infected mice receiving no further treatment ...