Not only did diffuse loss mean deviation appear, but abnormal areas appeared with high intraocular pressure in the present patient. If corneal edema affected visual field, only diffuse loss would occur. Refractive error was corrected at examination of FDT. Good visual acuity was maintained under high intraocular pressure. In conclusion, FDT perimetry may show intraocular pressure–dependent, rev...

Patients receive blood thinners (anticoagulants) to treat or prevent blood clots. The most commonly used intravenous anticoagulant is heparin. This Cardiology Patient Page focuses on heparin-induced thrombocytopenia (HIT), a complication of heparin therapy. This complication of heparin is often confusing because in HIT, heparin does the opposite of what it is supposed to do: It forms rather tha...

Heparin is a drug widely used for thromboprophylaxis or treatment in many clinical situations. However, it can cause serious adverse effects, including thrombocytopenia, which is a potentially life-threatening condition. Unfortunately, heparin-induced thrombocytopenia is generally under-recognised and under-diagnosed. A case of heparin-induced thrombocytopenia occurring in a post-operative orth...

Heparin-induced thrombocytopenia FABRIZIO FABRIS, GUIDO LUZZATTO, PIERO MARIA STEFANI, BRUNO GIROLAMI , GIUSEPPE CELLA,

Heparin-induced thrombocytopenia (HIT) is a growing complication of a common medication used to prevent deep vein thrombosis (DVT) in hospitalized patients. The purpose of this article is to review the mechanism that causes paradoxical thrombus formation in HIT and ways to recognize this important complication with various testing modalities and to discuss the approaches to treatment once a dia...

Rifampicin occasionally causes thrombocytopenia when given as part of an intermittent regimen. A case is reported of severe thrombocytopenia developing after one dose of rifampicin, following a 4-month gap in daily therapy. The literature on rifampicin-induced thrombocytopenia is reviewed.

Sera from 14 patients who developed heparin-induced throm bocyto­ penia were tested by an indirect platelet im m unofluorescent test in an a ttem pt to characterize the serologic reactions betw een platelets, heparin, and the antibody. Positive results were observed in seven cases with vari­ able patterns of reactions in the tests when perform ed in the presence or the absence of the offending ...

Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxal...

Antibodies to CD44 have been used to successfully ameliorate murine models of autoimmune disease. The most often studied disease model has been murine inflammatory arthritis, where a clear mechanism for the efficacy of CD44 antibodies has not been established. We have recently shown in a murine passive-model of the autoimmune disease immune thrombocytopenia (ITP) that some CD44 antibodies thems...