Background: Angiotensin converting enzyme (ACE) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin II that is a vasoconstrictor and mitogen factor. To date, the role of angiotensin II on regulating blood flow in inflamed joints has not been studied. Methods: Acute and chronic joint inflammation was induced in rabbits by intra-articular...

Knowledge about the induced pathogen resistance of plants is rapidly increasing, but little information exists on its dependence on abiotic growing conditions. Arabidopsis thaliana plants that had been cultivated under different nitrogen regimes were treated with BION ® , a chemical resistance elicitor. The activities of three enzyme classes functionally involved in resistance (chitinase, chito...

The primary player that induces insulin resistance has not been established. Here, we studied whether or not fat can cause insulin resistance in the presence of insulin deficiency. Our results showed that high-fat diet (HFD) induced insulin resistance in C57BL/6 (B6) mice. The HFD-induced insulin resistance was prevented largely by the streptozotocin (STZ)-induced moderate insulin deficiency. T...

background: all aerobically growing organisms suffer from exposure to oxidative stress, caused by partially reduced forms of molecular oxygen, known as reactive oxygen species (ros). these are highly reactive and capable of damaging cellular constituents such as dna, lipids and proteins. consequently, cells from many different organisms have evolved mechanisms to protect their components agains...

background resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (t2d); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them. objectives in this study, we aimed to assess the effect of three months of resistance training on tcf7l2 expression in pancreatic tissues, serum insulin and gluc...

Oxidative stress has become an important subject for terrestrial and aquatic toxicology. The trace element selenium has been demonstrated in chemo-prevention and drug-resistance through reduction of oxidative stress. Selenium compounds could prevent damage to the unsaturated fatty acid of subcellular membranes by lipid peroxidation induced by free radicals in fish.  

heparin- induced thrombocytopenia (hit) is an antibody mediated adverse effect of heparin therapy which is classified into two subtypes, hit i which is non-immune, spontaneously reversible thrombocytopenia and; hit ii which is an autoimmune-mediated adverse effect of heparin therapy. in this case report, we described a 65-year old male patient with hit ii after coronary artery bypass grafting. ...