To elucidate the role of cyclooxygenase (COX)-2 in ulcer healing, we compared the effects of NS-398 (COX-2-selective inhibitor) and indomethacin (nonselective COX inhibitor) on the healing of acetic acid-induced gastric ulcers in rats. Prostaglandin E2 (PGE2) production was elevated in ulcerated tissue, but remained unaffected in intact tissue. COX-2 mRNA was only detected in the ulcerated tiss...

It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as com...

Gastric ulcer is one of the most common diseases gastrointestinal system and some its complications are main causes morbidity mortality. Bromelain (BRM), a sulfhydryl proteolytic enzyme, has multiple activities in many areas medicine as an antioxidant anti-inflammatory agent. In this study, it was aimed to investigate oxidative stress-mediated therapeutic effect BRM gastric model induced by ind...

The methanolic extract of the leaves of C. mucronata was screened for anti-ulcer properties using animal models. On isolated guinea pig ileum the extract inhibited contractions evoked by acetylcholine, histamine and serotonin. The extract remarkably decreased the propulsive movement of gastrointestinal content. The extract exhibited significant anti-ulcer activity protecting rats from indometha...

AIM To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, "Pimpinella anisum L." on experimentally-induced gastric ulceration and secretion in rats. METHODS Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. A...

Momordica charantia (MC) is popular for its medicinal uses especially treating diabetic-related complications. However, the antiulcer activity of essential oil derived from seeds has not been systematically studied. This study aims to evaluate gastroprotective activities seed MC induced by hydrochloride acid/ethanol (HCl/EtOH) and indomethacin pylorus-ligation model. Gastric ulceration was oral...

Turmeric (Curcuma longa) L rhizome powder (TRP) was commonly reported to have antiulcerogenic and non-toxicity effects. However, the scientific evidence showing effectiveness of turmeric in treatment gastric ulcer its effect are controversial. The aim study investigate effects different percentages supplemented diet on toxicity induced by indomethacin Wistar rats. This investigated TRP formulat...

OBJECTIVE The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP). MATERIALS AND METHODS MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol- and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated. RESULTS At a dose of 5,0...

Proanthocyanidin (grape seed proanthocyanidin extracts, GSPEs) is an antioxidant and scavenges free radicals. Excessive oxidative stress and free radical production are major components in the pathogenesis of NSAID-induced small intestinal injury. We investigated the effect of GSPEs on indomethacin-induced intestinal mucosal injury in the rat. Rats were allocated into four groups: the null cont...