The indolizidine alkaloid-swainsonine (SW) is the main toxic component of locoweeds and cause locoweed poisoning in grazing animals. endophytic fungi, Alternaria Section Undifilum spp., are responsible for biosynthesis SW locoweeds. swnK gene a multifunctional complex enzyme encoding fungal biosynthesis, its product plays key role multistep catalytic synthesis by fungi using pipecolic acid as p...

Readily prepared 2-alkyl-2-azidopropylcycloalkyl-1,3-diones undergo intramolecular Schmidt rearrangement with a range of hard Lewis acids, leading to indolizidinediones and pyrroloazepinediones. Chiral aluminium-based Lewis acids could also be used to mediate this symmetry-breaking transformation, but no significant asymmetric induction was observed.