OBJECTIVE We aimed to investigate the effect of topical application of a Copper indomethacin (Cu-Indo) gel preparation on monosodium iodoacetate (MIA) induced arthritis of the knee joint of rats and to test our hypothesis that copper complex of indomethacin could be a more potent anti-inflammatory agent than its parent compound. METHODS After induction of osteoarthritis by the intracapsular i...

Aim In the Indo-Pacific, the mass of islands of the Indonesian archipelago constitute a major biogeographical barrier (the Indo-Pacific Barrier, IPB) separating the Pacific and Indian oceans. Evidence for other, more localized barriers include high rates of endemism at the Marquesas and other isolated peripheral islands in the Pacific. Here we use mitochondrial-sequence comparisons to evaluate ...

Geophysical evidence strongly supports the complete isolation of India and Madagascar (Indo-Madagascar) by ∼100 million years ago, though sparse terrestrial fossil records from these regions prior to ∼70 million years ago have limited insights into their biogeographic history during the Cretaceous. A new theropod dinosaur, Dahalokely tokana, from Turonian-aged (∼90 million years old) strata of ...

The cosmological constant problem is seen as a symptom of the ambiguity of the Riemann curvature in general relativity. The solution of that ambiguity provided by Nash's theorem on gravitational perturbations along extra dimensions eliminate the direct comparison between the vacuum energy density and Einstein's cosmological constant, besides being compatible with the formation of structures and...