Mitotic spindle position is controlled by interactions of cortical molecular motors with astral microtubules. In animal cells, Partner of Inscuteable (Pins) acts at the cortex to coordinate the activity of Dynein and Kinesin-73 (Khc73; KIF13B in mammals) to orient the spindle. Though the two motors move in opposite directions, their synergistic activity is required for robust Pins-mediated spin...

Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple mo...

a response to the problem of irans backwardness preoccupied the minds of intellectual and political forces. since irans failure from russia while different domestic and external factors caused to defeat, differend and even contending views concerning irans backwardness played a key role in these failures. these diverse and contending views which arised at first in compilation of laws and establ...

the purpose of this study is to provide a model for performance evaluation of sepah bank branches by using partial indicators through combining controllable and uncontrollable potential variables with performance variables. with description and expansion of performance concepts of branches, a complete list of pre-test variables, including forty nine potential variables and five performance vari...

Observers show small but systematic deviations from equal weighting of all elements when asked to localize the center of an array of dots. Counter-intuitively, with small numbers of dots drawn from a Gaussian distribution, this bias results in subjects overweighting the influence of outlier dots - inconsistent with traditional statistical estimators of central tendency. Here we show that this a...

from the perspective of theorists of international relations including functionalists and regionalists, establishment of cooperation and economic, commercial and transportation relations is among the suitable methods for fostering integration in international relations and deepening friendship, peace and stability particularly among regional countries. considering this fact, the authors believe...

Successful embryo implantation requires complex interactions between the uterus and embryo, including the establishment of maternal immunologic tolerance of fetal material. The maternal-fetal interface is dynamically populated by a wide variety of innate immune cells; however, the relevance of uterine DCs (uDCs) within the decidua to the success of implantation has remained unclear. In this iss...

Invasive alien species (IAS) threaten human livelihoods and biodiversity globally. Increasing globalization facilitates IAS arrival, and environmental changes, including climate change, facilitate IAS establishment. Here we provide the first global, spatial analysis of the terrestrial threat from IAS in light of twenty-first century globalization and environmental change, and evaluate national ...

T cells are critical to immunity against pathogenic Salmonella including Salmonella Typhi which causes systemic infection, typhoid, in humans. The strategies that this pathogen employs to keep T-cell mediated immune responses in check during establishment of systemic infection are not completely understood. Here, we show that the virulence polysaccharide Vi, which distinguishes S. Typhi from lo...