M A M M A L I A N ,&glucuronidase has been relatively well characterized with regard to such parameters as substrate specificity, tissue levels, pH dependence, intracellular localization, and protein structure. For a recent review the reader may consult LEVVY and CONCHIE (1966). Although this information failed to elucidate the physiolcigical role of glucuronidase, it has provided a convenient ...

Laboratory rats have been generally considered non-photoresponsive, but strains of laboratory rats have been found to be variable for this trait. Young males of both the Fischer (F344) and Brown Norway strains (BN) suppress reproductive development, food intake and body mass in short winter photoperiod (short days (SD); 8 h light:16 h darkness), and food restriction interacts with SD to enhance...

It is known that four common inbred mouse strains show defects of the forebrain commissures. The BALB/cJ strain has a low frequency of abnormally small corpus callosum, whereas the 129 strains have many animals with deficient corpus callosum. The I/LnJ and BTBR T+ tf/J strains never have a corpus callosum, whereas half of I/LnJ and almost all BTBR show severely reduced size of the hippocampal c...

Several variables have been reported to affect the expression of sex differences in the analgesic potency of morphine. Although the effect of genetic background on morphine analgesia has been well documented, the relevance of genotype to sex differences in morphine analgesia has rarely been considered. The present study investigated morphine dose-response relationships in male and female mice o...

Constants in equations of curves describing the geotropic orientation of young rats are repeatedly obtainable from litters of successive generations of the same inbred strains. Different inbred strains have been obtained for which the respective constants are quite unlike. Such findings show how necessary it is to employ biologically uniform material in experiments of this kind. And at the same...