نتایج جستجو برای: in vivo targeting

تعداد نتایج: 17011474  

Journal: :iranian journal of radiation research 0
k.v. sharma radiation biology laboratory, department of zoology, university of rajasthan, jaipur, india-302055 r. sisodia radiation biology laboratory, department of zoology, university of rajasthan, jaipur, india-302055

background: radioprotective efficacy of prunus avium fruit extract (pae) rich in vitamin a, c, e and anthocyanin was studied against radiation induced biochemical alterations in mice brain. materials and methods: in-vitro assays were performed with pae for its antioxidant studies thereafter for in-vivo study, swiss albino mice were divided into five groups. group 1 (control) normal mice. group ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان تهران - دانشکده علوم پایه 1388

مقدمه: اکسیداسیون ldl نقش مهمی در ایجاد آترواسکلروز دارد. استفاده از آنتی اکسیدانها در مواد غذایی باعث جلوگیری از اکسیداسیون ldl می شود و این باعث جلوگیری از ایجاد و پیشرفت آترواسکلروز می شود.دراین مطالعه اثرات ساچوریاخوزستانیکا برمهار اکسیداسیون ldl سرم درمحیط in vitro بررسی شده است. روشها: ldl پلاسمای تازه تهیه شده جدا شده، و بطور جداگانه با سولفات مس،انکوبه شد. جهت بررسی اکسیداسیون ldl مقدا...

Journal: :Organic & biomolecular chemistry 2012
Hiroyuki Nakamura Noriko Ueda Hyun Seung Ban Manabu Ueno Shoji Tachikawa

The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent intensities of the FL-SBL-labeled DSPC liposomes increased with the ...

Journal: :Chemical Society reviews 2015
J Bartelmess S J Quinn S Giordani

Carbon based nanomaterials have emerged over the last few years as important agents for biomedical fluorescence and Raman imaging applications. These spectroscopic techniques utilize either fluorescently labelled carbon nanomaterials or the intrinsic photophysical properties of the carbon nanomaterial. In this review article we present the utilization and performance of several classes of carbo...

2009
Shinae Kizaka-Kondoh Shotaro Tanaka Masahiro Hiraoka

Human solid tumors contain hypoxic regions that have considerably lower oxygen tension than normal tissues. They are refractory to radiotherapy and anticancer chemotherapy. Although more than half a century has passed since it was suggested that tumour hypoxia correlates with poor treatment outcomes and contributes to recurrence of cancer, no fundamental solution to this problem has been found....

2016
Stefan Wiehr Philipp Warnke Anna-Maria Rolle Monika Schütz Philipp Oberhettinger Ursula Kohlhofer Leticia Quintanilla-Martinez Andreas Maurer Christopher Thornton Frederic Boschetti Gerald Reischl Ingo B. Autenrieth Bernd J. Pichler Stella E. Autenrieth

The specific and rapid detection of Enterobacteriaceae, the most frequent cause of gram-negative bacterial infections in humans, remains a major challenge. We developed a non-invasive method to rapidly detect systemic Yersinia enterocolitica infections using immunoPET (antibody-targeted positron emission tomography) with [64Cu]NODAGA-labeled Yersinia-specific polyclonal antibodies targeting the...

2017
Xianghan Zhang Bo Wang Na Zhao Zuhong Tian Yunpeng Dai Yongzhan Nie Jie Tian Zhongliang Wang Xiaoyuan Chen

The traditional labeling method for targeted NIR fluorescence probes requires directly covalent-bonded conjugation of targeting domains and fluorophores in vitro. Although this strategy works well, it is not sufficient for detecting or treating cancers in vivo, due to steric hindrance effects that relatively large fluorophore molecules exert on the configurations and physiological functions of ...

2017
Maria Mir Saba Ishtiaq Samreen Rabia Maryam Khatoon Ahmad Zeb Gul Majid Khan Asim ur Rehman Fakhar ud Din

Science and technology have always been the vitals of human's struggle, utilized exclusively for the development of novel tools and products, ranging from micro- to nanosize. Nanotechnology has gained significant attention due to its extensive applications in biomedicine, particularly related to bio imaging and drug delivery. Various nanodevices and nanomaterials have been developed for the dia...

Journal: :Magnetic resonance imaging 2003
Thomas J Lowery Seth M Rubin E Janette Ruiz Megan M Spence Nicolas Winssinger Peter G Schultz Alexander Pines David E Wemmer

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and f...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
Hao Hong Yin Zhang Weibo Cai

RNA interference (RNAi), an effective technique for regulating or silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing, and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable...

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function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
  • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->