BACKGROUND We sought to identify gene polymorphisms that confer susceptibility to in-stent restenosis after coronary artery bare-metal stenting in a Central European population. METHODS 160 controls without post-percutaneous coronary intervention in-stent restenosis were matched for age, sex, vessel diameter, and diabetes to 160 consecutive cases involving in-stent restenosis of the target le...

Due to the widespread use of stents in complex coronary lesions, stent restenosis represents an increasing problem, for which optimal treatment is under debate. "Debulking" of in-stent neointimal tissue using percutaneous transluminal rotational atherectomy (PTRA) offers an alternative approach to tissue compression and extrusion achieved by balloon angioplasty. One hundred patients (70 men, ag...

Femoropopliteal (FP) artery-in stent restenosis (ISR) is a daunting management problem that we continue to face. FP artery-ISR rates after primary stent implantation are relatively high. Although repeat FP artery-ISR and the need for additional interventions remain all too common, little consensus exists regarding the best treatment algorithm. In this article, we review the limitations of the c...

Stents are now used in 40–80% of percutaneous coronary interventional procedures. This popularity is based upon extrapolation from available data, which discloses a better immediate angiographic appearance than after PTCA, an ability to ‘bail out’ poor PTCA results and superior late clinical and angiographic results compared with PTCA in certain lesion subsets. The enthusiasm for stents has tra...

Restenosis after coronary stent implantation remains the major limitation of this treatment modality. At present, re-dilatation is considered the therapeutic option of choice for focal lesions, however, long restenotic lesions (>10 mm) do not respond favourably. Despite the emerging concept of intracoronary radiation, encouraging acute procedural results are also reported for different debulkin...

as a means for catheter–based coronary revascularization has rapidly changed the face of interventional cardiology. At many leading centers, 60-70% of all percutaneous coronary interventions now utilize stenting. The relatively rapid acceptance and increasingly widespread use of stents has been driven by an improvement in the predictability of intervention with lessened acute and subacute closu...

Objective: To investigate the effect of reducing stent length on the rate of target lesion restenosis. Design: In a prospective investigation, acute and long term results of a short stenting procedure were analysed by quantitative angiography and compared with results of a conventional stenting procedure selected according to a matched pairs analysis. Patients: Short stents were implanted in 40...

OBJECTIVES The rationale of this study was to identify risk factors that predict early thrombotic events and angiographic restenosis after stenting in small coronary arteries. BACKGROUND Rates of cardiac complications and restenosis after percutaneous coronary intervention are higher in patients with small versus large coronary arteries. Because of discordant results, randomized studies compa...

We report a patient's case of slow progressive in-stent restenosis 10 years after bare-metal stent implantation to his carotid artery. We treated the patient with an additional stent placement under a distal filter protection device. Optical coherence tomographic assessment and plaque histology during the carotid artery stenting (CAS) revealed atheromatous change at in-stent neointima, which co...

OBJECTIVE To assess the impact of stent symmetry on restenosis using the coronary overstretch sheep model. METHODS Neointimal thickness, injury index, and percentage diameter and area stenosis were calculated by digital morphometry. The standard deviation of the angular burden was used to assess stent symmetry for each section. MATERIALS 15 healthy Merino sheep (63-75 kg) underwent implanta...