the present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. fourier transform infrared spectroscopy (ftir) and differential scannin...

purpose : to assess the outcomes of laser in situ keratomileusis (lasik) in patients with multiple sclerosis (ms) methods : 15 eyes of 8 patients with ms (2 men and 6 women) who referred for myopia treatment (with or without astigmatism) were undergone lasik. after refractive and visual acuity examinations, topographic and pachymetry screening, intraocular pressure (iop) measurement, biomicrosc...

hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. these interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...

abstract  background: spondylolysis and spondylolisthesis can be associated with significant  low back pain, especially in physically active adolescents. non-operative management  is usually successful in improving symptoms, but surgical intervention is  occasionally required. the aim of this study was to determine the effect of in situ posterolateral  fusion in the treatment of refractory case...

malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. however, association of apocrine metaplasia in papilloma with ductal carcinoma in situ (dcis) is not very well defined. the lesions with apocrine metaplasia are not only di...

To completely understand wear mechanisms of mixed ceramic cutting tools (Al 2 O 3-TiC), residual stress states and the superposition of external loads during hard turning should be investigated. This can be done via X-ray diffraction using high-energy synchrotron radiation to determine lattice strains in the material. For this reason, in first model tests, strain states in mixed ceramics were d...

background: it has been claimed that by using different washing methods, the sperms can be separated according to size, motility, density, chromosomal content and surface markings and charge. these methods also reduce sperm chromatin deficiencies and screen the sperms before applying in assisted reproduction techniques. objective: this study compared simple density gradient methods and a combin...

purpose: to evaluate and compare tear secretion and tear film instability following laser in situ keratomileusis (lasik) and laser assisted subepithelial keratectomy (lasek). methods: in a randomized clinical trial, 30 eyes of 15 patients underwent lasik and 30 eyes of 15 patients underwent lasek to correct myopia. tear secretion and tear film instability were tested preoperatively, 2 and 6 wee...