Long-term potentiation (LTP) is a type of synaptic plasticity characterized by an increase in synaptic strength and believed to be involved in memory encoding. LTP elicited in the CA1 region of acute hippocampal slices has been extensively studied. However the molecular mechanisms underlying the maintenance phase of this phenomenon are still poorly understood. This could be partly due to the va...

Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-depend...

   Two omega-3 fatty acids including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential for the physiologic function of neuronal cell membrane. Normal function of neuronal cell membrane requires appropriate composition of fatty in its structure. Present study was designed to compare the effect of short-term and long-term pretreatment with omega-3 fatty acids on scopolamine...

Long-term memory underlying Pavlovian fear conditioning is believed to involve plasticity at sensory input synapses in the lateral nucleus of the amygdala (LA). A useful physiological model for studying synaptic plasticity is long-term potentiation (LTP). LTP in the LA has been studied only in vitro or in anaesthetized rats. Here, we tested whether LTP can be induced in auditory input pathways ...

we aimed to evaluate clinical, high resolution computed tomography (hrct) and pulmonary function test (pft) findings after 18-23 years of exposure in veterans of sulphur mustard (sm) exposure. we performed a cross-sectional study of 106 patients. inclusion criteria were 1: documented exposure to sm as confirmed by toxicological analysis of their urine and vesicular fluid after exposure 2: singl...

the influence of long-term mixed organic and inorganic contamination on soil microbial activity, community structure and genetic diversity was investigated in soil samples from a coke oven plant located in upper silesia, poland. the tested soils were heavily contaminated with polycyclic aromatic hydrocarbons (pahs) and heavy metals. the microbial communities were characterized using the phospho...

introduction: langerhans cell histiocytosis (lch) is a rare disease characterized by clonal prolifera-tion of histiocytosis in different tissues. permanent consequences (pc) described among subjects with langerhans cell histiocytosis (lch).in this study we report the prevalence of permanent sequel among long – term survivors of lch in our center. methods: we had 30 cases of lch from 1989 – 2001...

background: spermatogonial stem cells are subpopulation of spermatogonial cells in testis tissue that support beginning and maintenance of spermatogenesis. ubiquitin carboxy-terminal hydrolase l1 (uchl1) could be a specific marker for identification of spermatogonial stem cells including spermatogonial sperm cells (sscs) in testis tissue and during the culture; therefore we undertook this study...