Several nonpeptide small molecules were designed as potential inhibitors of HIV protease and their structures were constructed by computer-aided molecular modeling and docked iwo the active site of HIV protease. Models of the complexes of inhibitors and the HIV protease were refined using nonbonded and H-bonding terms. The refined energy of selected complexes showed that the designed inhib...

a better understanding of the mechanism of chromosomal aberration formation could be obtained by using dna repair inhibitors. immortalized normal human (mrc 5 svi) and ataxia telangiectasia ( at 5 biv a ) fibroblastic cell lines were treated with adenosine arabinoside (ara-a) and cytosine arabinoside (ara-c), both potent inhibitors of dna dsb repair, alone or in combination with x-rays at g2 or...

bypassing agents are the most commonly used medicines for the treatment of hemophilia patients with inhibitors. the aim of this study is to identify the cost components of management of bleeding vents in hemophilia patients with inhibitors in iran. this study is a cross-sectional study using a bottom-up approach to determine the cost components of treatment of hemophilia patients with inhibitor...

Interactions of 3,3',4,4'-tetrahydroxybiphenyl (BPT) and three isomeric 3,3",4,4"-tetrahydroxyterphenyls (OTT, MTT, PTT) with Alzheimer’s amyloid-β peptide (Aβ) were studied by molecular dynamics simulation and molecular docking. Structural parameters such as Root-mean-square derivations (RMSD), radial distribution function (RDF), helix percentage and other physical parameters were obtained. Th...

the effect of four inhibitors on calmalulin (cum) were studied by a ftuorescence and ultraviolet techniques. four compounds in - ( 6 - aminohexyt) 5-chloro - i - napthalenesulphonamide] (w-7), 1 - [ bis - (4 - chtorophenyt) methyl] - 3 - [2, 4-dichloro - β - ( 2 , 4 - dichlorobenzyloxyl) phenethyt] imidazolium chloride (r24571), trifluoperazine (tfp) , thiodiphenylamide chloride (tdpac) showed ...

a fundamental study of scale formation of calcium carbonate (caco3) for producing oil wells hasbeen carried out. this article presents the study of the prediction of salt deposition in two differentsynthetic formation waters and investigates the effects of temperature and pressure on calciumcarbonate precipitation. the dependence of the induction period of the precipitation of calciumcarbonate ...

cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (ca). hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expression of plasm...

the objective of this study is to study the effect of citrus medica in urolithiasis induced by ethylene glycol model. a number of 24 male wistar albino rats (250-300 g) were divided in to 4 groups namely group i (normal control), group ii (model control), group iii (standard-treated, cystone – 750 mg/kg) and group iv (citrus medica – 250 mg/kg). except group i, ethylene glycol (0.75% v/v in dri...

inhibitors of soluble epoxide hydrolase (seh) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. most of the potent seh inhibitors reported in literature often suffer from poor solubility and bioavailability. toward improving pharmacokinetic profile beside favorable potency, two series of 4-benza...

Background: Acid phosphatase (ACP) is suggested to be one of the virulence factors in leishmania and a correlation has been reported between Leishmanial acid phosphatase (ACP) activity and the severity of the disease in all types of leishmaniasis including zoonotic cutaneous leishmaniasis (ZCL), which is a polymorphic disease. Objective: Characterization of leishmania and its correlation with t...