نتایج جستجو برای: immunosuppressive drug
تعداد نتایج: 607565 فیلتر نتایج به سال:
Bioequivalence of twice-daily oral tacrolimus in transplant recipients: More evidence for consensus?
In this Perspective on the clinical trial by Rita Alloway and colleagues, Simon Ball explains the benefits to healthcare systems and individual patients of the bioequivalence established between generic and brand-name formulations of an immunosuppressive drug in transplant recipients.
balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...
background cytokines are secreted signaling proteins which play essential roles in immune responses during experimental autoimmune encephalomyelitis (eae), a demyelinating model that mimics many features of multiple sclerosis (ms). interleukin 6 (il-6) is a multifunctional cytokine produced by different cells, mediating inflammatory reactions and immune-mediated processes. several studies have ...
We have studied the effect of amitriptyline, a tricyclic anti-depressant drug on several immune parameters of the Balb/c mice in order to evaluate its immunomodulatory effects. Results showed that amitriptyline will potentiates all of the immunocytes functions except for the production of PGE2 by LPS stimulated monocytes. We have also showed that amitriptyline can normalize the immunosuppressiv...
background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...
Temozolomide (TMZ) is a new cytotoxic triazene compound of clinical interest that is able to generate methyl adducts at the O(6)-guanine of DNA, which can be repaired by O(6)-alkylguanine-DNA alkyltransferase (OGAT). It was previously found that triazene compounds are highly immunosuppressive in mice. In the present study, we investigate whether TMZ could affect immune functions of human compet...
Continued improvement in the long-term survival of heart transplant recipients has resulted in a population of patients with prolonged exposure to immunosuppressive drugs.1 This exposure, coupled with the increasing age of recipients, has resulted in an impressive prevalence of comorbidities in these patients. Indeed, by 5 years after transplantation, 95% of recipients have hypertension, 81% ha...
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with ocular inflammatory diseases. Demographic, clinical, and treatment data derived from medical reco...
The introduction of the immunosuppressive agent mycophenolate mofetil as a standard-dose drug has resulted in a reduced risk of rejection after renal transplantation and improved graft survival compared to azathioprine. The favorable balance between efficacy and safety has made mycophenolate mofetil a cornerstone immunosuppressive drug, and the vast majority of newly transplanted patients are n...
Histone H1 and high-mobility group box 1 (HMGB1) proteins are known to initiate an immune reaction, and the corresponding antibodies (Abs) possess immunosuppressive activity. In the present study, we aimed to evaluate the immunological role of antinuclear Abs in experimental and clinical liver transplantation. In a rat tolerogenic orthotopic liver transplantation (OLT) model, antihistone H1 and...
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