Melanoma is the deadliest form of skin cancer in the United States with an increasing prevalence. However, the development of melanoma from a melanocyte precursor is still poorly defined. Understanding the molecules responsible for melanoma progression may lead to improved targeted therapy. One potential molecule is the paired box-3 (PAX-3) protein, which has been implicated in the development ...

Tumor recurrence remains the major cause of management failure after surgical resection glioblastoma (GBM). Immunotherapy has potential to effectively eradicate tumors and trigger immune memory prevent tumor but not improve outcomes GBM patients. Here, an injectable, reactive oxygen species-degradable therapeutic hydrogel ([email protected]), capable sustained local release soluble PD-1 (sPD-1)...

Highlight Research Development of immunostimulant from natural sources is a promising approach to improve the immune status fish Dietary administration sodium alginate Padina australis at 2.0 g/kg was an effective for red tilapia Red fed diet with significantly increased innate responses TLC, PA, respiratory burst, SOD, TPP, lysozyme, and ACH50 activity modulated genes expression GPx, TNF-α, IF...

Immune checkpoint inhibitors (ICIs) are a novel cancer therapy that may induce tumor regression across multiple types of cancer. There has recently been interest in combining the ICIs with other forms treatments, as not all patients benefit from monotherapy. We propose mathematical model consisting ordinary differential equations to investigate combination treatments ICI avelumab and immunostim...