Boron neutron capture therapy (BNCT) is a tumor selective therapy, the effectiveness of which depends on sufficient 10B delivery to and accumulation in tumors. In this study, we used self-assembling A6K peptide nanotubes as boron carriers prepared new agents by simple mixing BSH. BSH has been treat malignant glioma patients clinical trials its drug safety availability have confirmed; however, c...

The gastric ganglion is the largest visceral ganglion in cephalopods. It is connected to the brain and is implicated in regulation of digestive tract functions. Here we have investigated the neurochemical complexity (through in silico gene expression analysis and immunohistochemistry) of the gastric ganglion in Octopus vulgaris and tested whether the expression of a selected number of genes was...

red hot pepper is a plant that belongs to the solanaceae family and is known as capsicum annuum. capsaicin is the active ingredient of cayenne pepper. ghrelin is a hormone, which consists of polypeptide structure. ghrelin also contributes to growth hormone secretion, energy balance, food intake and body weight regulator. the aim of this study was the localization and expression of ghrelin in th...

the respiratory tract contains numerous peptides secreted from special pulmonary epithelial cells whichare called endocrine cells. the function of neuroendocrine cells is modulated by amines. serotonin has strong vasomotor and bronchomotor effects in the airway mucosa. the objective of this study was to determine presence and distribution of serotonin-positive endocrine cells in respiratory tra...

granular cell tumors are rare neoplasms of uncertain histogenesis but with a typical histologic appearance composed of cells with characteristic granular cytoplasm. these tumors occur most often in adults as an asymptomatic solitary papule or nodule. multiple granular cell tumors are rare, especially in children and teenagers. we represent a case of multiple granular cell tumors in a 19-year-ol...

background: helicobacter pylori, which is associated with many upper gastrointestinal diseases, is found in half of the population of the world. several special stains and immunohistochemistry stain for h. pylori are available. the need for and usefulness of immunohistochemical (ihc) technique has been debated for years. toluidine blue is a simple stain for microbiological studies and is easily...

background and objectives: baculovirus can be used as a vector in gene delivery system. viral envelope of baculovirus would display expressed protein/peptide and it could render as a potential vaccine delivery system. in this regard, the gene coding for a subunit of shiga toxin (stxa) from escherichia coli ( e. coli ) strain was cloned in a baculovirus expression system. stxa subunit has the ab...

b ackground: l eishmania is an intracellular parasite infecting humans and many wild and domestic animals. recent studies have suggested an important role for cytotoxic t cells against leishmania . peptide-based vaccines targeting short sequences derived from known immunogenic proteins have been shown to elicit cellular immune responses against disparate pathogens. m ethods: we predicted four h...