The Lewis blood group system comprises two main carbohydrate antigens, Le(a) and Le(b). Lewis typing has traditionally been based on serologic determinations using erythrocytes and saliva. Several recent studies have demonstrated that erythrocyte Lewis phenotype may change during pregnancy or disease, and inappropriate Lewis antigens have been found in both normal and neoplastic tissue. To eval...

Labelling and identifying proliferating cells is central to understanding neurogenesis and neural lineages in vivo and in vitro. We present here a novel thymidine analogue, ethynyl deoxyuridine (EdU) for labelling dividing cells, detected with a fluorescent azide which forms a covalent bond via the "click" chemistry reaction (the Huisgen 1,3-dipolar cycloaddition reaction of an organic azide to...

BACKGROUND Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related pollution on the allergenicity of ragweed (Ambrosia artemisiifolia L.) polle...

From the Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Department of Immunochemistry and Biochemical Microbiology, Emmy Noether Group of Immunobiophysics, Division of Biophysics, Division of Immunology, 23845 Borstel, Germany EMC microcollections GmbH, 72070 Tübingen, Germany **Institute of Organic Chemistry, University of Tübingen, 72076 Tübingen, Germany European Molec...

From the * Laboratory of Tumor Immunology, the ‡ Cancer Immunotherapy and Gene Therapy Program, and the § Laboratory of Molecular Tissue Typing and i Immunochemistry Unit, Department of Biology and Technology (DIBIT), Scientific Institute H. San Raffaele, 20132 Milan, Italy; ¶ Roche Milano Ricerche, 20132 Milan, Italy; ** Roche Discovery Technologies, Hoffman-La Roche, Inc., Nutley, New Jersey ...

Keloidal atypical fibroxanthoma (KAF) has recently been categorized as a variant of atypical fibroxanthoma. This paper will emphasize the importance of including KAF in both clinical and histological differential diagnosis of benign and malignant lesions which exhibit keloidal collagen and will also review the current literature on epidemiology, pathogenesis, histology, immunochemistry and trea...