L EUKOCYTE TYPING may prove to be an important guide in determining histocompatibility relationships between donor and recipient in tissue l 2 Most studies directed towards ascertaining correlations between human leukocyte factors are carried out with batteries of multispecific antisera. The reactions of such antisera tend, unfortunately, to mask antigenic differences between closely linked fac...

The role of bivalence of antibody in its capacity to neutralize virus was studied with rabbit antibodies to the bacteriophage, phiX174. Univalent Fab or Fab' fragments of IgG isolated from antiviral antisera obtained early in the immunization schedule had virtually no activity compared to that of the intact IgG. When the antibodies were isolated from antisera of the same rabbits several months ...

Modifications in the antiserum agar method for serogroup identification of meningococci, which reduce the amount of group-specific antisera required and increase long-term storage of prepoured antiserum agar plates, are described.

The ability of virulent strains of Aeromonas salmonicida to resist the bactericidal activity of serum was quantitated. The A. salmonicida strains tested included virulent strains, mutants lacking the major surface A-protein, and mutants lacking A-protein and having a modified lipopolysaccharide structure. The sera evaluated included normal human, rabbit, and trout sera, immune trout serum, and ...

While the phagocytosis of Renibacterium salmoninarum by rainbow trout macrophages in vitro occurred in the absence of serum factors, opsonized bacteria once phagocytosed survived for a longer period than bacteria not exposed to serum. Immune sera favoured survival to a greater extent than non-immune sera. Although heat-inactivated immune sera reduced the extent of bacterial killing, bacterial p...

Surface serology is an important determinant in Spiroplasma systematics. Reciprocal antigen/antibody reactions between spiroplasmas and individual antisera delineate the 38 described groups and species. However, reciprocal serology is impractical for large-scale studies. This report describes a successful, streamlined polyvalent screening approach used to examine isolates from an environmental ...