Although tumors naturally prime adaptive immune responses, tolerance may limit the capacity to control progression and can compromise effectiveness of immune-based therapies for cancer. Post-proline cleaving enzymes (PPCE) modulate protein function through N-terminal dipeptide cleavage and inhibition of these enzymes has been shown to have anti-tumor activity. We investigated the mechanism by w...

This study was conducted to investigate the effects of Curcuma zedoaria and Zingiber zerumbet on non-specific immune responses of grouper (Epinephelus coioides). Fish were fed an experimental diet containing 0, 0.5, 1.0, 2.5 g/kg of C. zedoaria and Z. zerumbet mixed diets twice daily for two weeks. Non-specific immune parameters such as respiratory burst activity, reactive oxygen species, phago...

Studies have demonstrated that plant extracts possess various biological characteristics, including immunomodulatory activity. Heracleum persicum Desf. (Apiaceae), a medicinal plant native to Iran, was studied for its immunomodulatory activity. Immunomodulatory activity of different doses of an aqueous extract of H. persicum, was evaluated in female Swiss albino mice. Mice were treated with thr...

background: determination of digestive enzymes activity would provide critical information in the design of appropriate diet. sobaity, sparidentex hasta is found in the persian gulf and  cultured in countries adjacent to it. objectives: this study investigated proteolytic, amylase and lipase activities in the intestine of sparidentex hasta captured from the  persian gulf. methods: 60 immature s...

plants and soil microbes are the main sources of most enzymes available in the environment. it is, therefore, anticipated that any change in the growth of soil biota in response to salinity, may reduce the synthesis and production of extra- and intra- cellular enzymes. as a result, a reduction in the growth of plants and the activity of soil microbes in saline environments may lessen the level ...

drought resistance is a very important characteristic needed for plant survival especially at germination stage, in arid and semi-arid lands. phosphatase enzymes are widely found in plants. these enzymes are responsible for dephosphorylation of organic phosphate and altering it to mineral phosphate. germination experiments were conducted in two bread wheat cultivars (sardari and alvand) under s...

BACKGROUND/AIM Chronic echinococcocal disease is the parasite human disease caused by the penetration of larval (asexual) stages of the canine tapeworm (Echinococcus granulosus) in the liver of humans. After the penetration of the parasite, the host organism react by activating complement-depending immune response. The aim of this study was to elucidate the influence of larval form of Echinococ...

Cellular metabolism plays a central role in the regulation of both innate and adaptive immunity. Immune cells utilize metabolic pathways to modulate cellular differentiation or death. The intricate interplay between immune response is critical for maintaining homeostasis effective antiviral activities. In recent years, immunometabolism induced by viral infections has been extensively investigat...