High-affinity receptors for interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are composed of two distinct subunits, a ligand-specific a chain and a common b chain (bc). Whereas the mouse has two homologous b subunits (bc and bIL-3), in humans, only a single b chain is identified. We describe here the isolation and characterization of the gene encoding th...

Involuntary inhalation of tobacco smoke has been shown to aggravate the allergic response. Antibodies to fungal antigens such as Aspergillus fumigatus (Af) cause an allergic lung disease in humans. This study was carried out to determine the effect of environmental tobacco smoke (ETS) on a murine model of allergic bronchopulmonary aspergillosis (ABPA). BALB/c mice were exposed to aged and dilut...

Spaceflights are known to induce stress and immune dysregulation. Centrifugation, as hindlimb unloading, is a good ground based-model to simulate altered gravity which occurs during space missions. The aim of this study was to investigate the consequences of a long-term exposure to different levels of hypergravity on the stress response and the humoral immunity in a mouse model. For this purpos...

Itch is often exacerbated by psychological stress in patients with atopic dermatitis (AD). However, how influence AD-associated itch and the underline mechanisms remain largely unknown. To investigate effect of on behaviors AD-like mice model, we employed a MC903 mouse model AD exposed both vehicle-treated MC903-treated C57BL/6 to 1-hour restraint daily for 7 days. On day 2, observed approximat...

After the pivotal randomized controlled trial in which patients with eosinophilic granulomatosis polyangiitis (EGPA) received 300 mg mepolizumab every 4 weeks, US Food and Drug Administration expanded approved use of to treat EGPA. Conversely, Europe, is not yet licensed for EGPA severe asthma, clinicians can only 100 mg/4 wk regimen that has already been these patients. Therefore, we read grea...

in this study, we aimed at studying the benefit of urtica dioica root extract in the management of allergic rhinitis. in a randomized double blind clinical trial, 74 patients with the signs and symptoms of allergic rhinitis and a positive skin prick test were randomly divided into 2 groups. the study group was treated with routine allergic rhinitis treatment and nettle root extract (urtidin®, b...

BackgroundChronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings.ObjectiveThe aim of this study was to analyze the expression cytokines, prostaglandin (PG) synthases, and their receptors related pathogenesis CRS, especially those contributing nasal polyp (NP) formation.MethodsNPs uncinate tissue (UT) samples were collected from 90 patients who unde...

Antecedentes: El asma es una enfermedad inflamatoria crónica de vías respiratorias, provocada por células y mediadores inflamatorios, asociado a disfunción del músculo liso, provocando obstrucción variable flujo aereo. Con mecanismos inmunoinflamatorios tipo 2 altos, bajos mixtos (endotipos). Asma grave aquella que requiere paso 4 o 5 tratamiento (GINA 2023). fenotipo TH2 Alto, no alergico con ...

The neural crest gives rise to numerous cell types, including Schwann cells, neurons, and melanocytes. The extent to which adult neural crest-derived cells retain plasticity has not been tested previously. We report that cutting adult mouse sciatic nerve induces pigmentation around nerve fascicles, among muscle bundles, and in the hypodermis. Pigmented cells are derived from adult nerve, becaus...