نتایج جستجو برای: il1β

تعداد نتایج: 533  

2016
Kosaku Sawada Masako Fujioka-Kobayashi Eizaburo Kobayashi Jens O. Brömme Benoit Schaller Richard J. Miron

BACKGROUND High dose radiation therapy is commonly used in maxillofacial surgeries to treat a number of head and neck tumors. Despite its widespread use, little information is available regarding the effects of irradiation on bone cell viability and release of growth factors following dose-dependent irradiation. METHODS Bone samples were collected from porcine mandibular cortical bone and irr...

Journal: :Heliyon 2023

Background and aimAlthough studies have associated elevated prenatal obesity with increased risk of various diseases in offspring, little is known regarding the immune system. The aim this study was to evaluate relationship between levels cytokines umbilical cord blood development allergic disease during first 10 years life an offspring.MethodsA cohort term infants born at ShaoXing Women Childr...

Journal: :Journal of lipid research 2013
Megan L Jones Peter J Mark Jeffrey A Keelan Anne Barden Emilie Mas Trevor A Mori Brendan J Waddell

Placental inflammation is associated with several pregnancy disorders. Inflammation is limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated by resolvins and protectins derived from omega-3 polyunsaturated fatty acids (n-3PUFA). We examined effects of dietary n-3PUFAs on levels of resolvins, protectins, and lipoxygenase (ALOX) enzymes in the rat placenta. Rats con...

Journal: :Cancer research 2014
Xiaoyi Zhang J Madison Hyer Hong Yu Nisha J D'Silva Keith L Kirkwood

DUSP1 is a dual-specificity phosphatase that regulates mitogen-activated protein (MAP) kinase activity. Studies have associated loss of DUSP1 expression with certain cancers, but there has been no report of a mechanism by which this supports tumor progression. In this study, we found DUSP1 mRNA and protein decreased in human head and neck squamous cell carcinoma tissues compared with adjacent n...

2013
Jiwang Chen Gang Feng Yang Song Juliane B. Wardenburg Simon Lin Ichiro Inoshima Michael Otto Richard G. Wunderink

BACKGROUND Linezolid (LZD) is beneficial to patients with MRSA pneumonia, but whether and how LZD influences global host lung immune responses at the mRNA level during MRSA-mediated pneumonia is still unknown. METHODS A lethal mouse model of MRSA pneumonia mediated by USA300 was employed to study the influence of LZD on survival, while the sublethal mouse model was used to examine the effect ...

2016
Biao Yang Dongmei Chen Hui Zhao Chunling Xiao

BACKGROUND Increasing urbanization and associated air pollution, including elevated levels of particulate matter (PM), are strongly correlated with the development of various respiratory diseases. In particular, PM2.5 has been implicated in promoting lung cancer initiation, growth and progression. Cell migration and proliferation are crucial for the progression of cancer. However, the molecular...

2016
Yalong Dang Yalin Mu Kun Wang Ke Xu Jing Yang Yu Zhu Bin Luo

OBJECTIVE To investigate the effects of papaverine (PAP) on lipopolysaccharide (LPS)-induced microglial activation and its possible mechanisms. MATERIALS AND METHODS BV2 microglial cells were first pretreated with PAP (0, 0.4, 2, 10, and 50 μg/mL) and then received LPS stimulation. Transcription and production of proinflammatory factors (IL1β, TNFα, iNOS, and COX-2) were used to evaluate micr...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016
Sharon R Pine Leah E Mechanic Lindsey Enewold Elise D Bowman Bríd M Ryan Michele L Cote Angela S Wenzlaff Christopher A Loffredo Susan Olivo-Marston Anil Chaturvedi Neil E Caporaso Ann G Schwartz Curtis C Harris

BACKGROUND African Americans have a higher risk of developing lung cancer than European Americans. Previous studies suggested that certain circulating cytokines were associated with lung cancer. We hypothesized that variations in serum cytokine levels exist between African Americans and European Americans, and increased circulating cytokine levels contribute to lung cancer differently in the tw...

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