Background: Glycogen Synthase Kinase-3 (GSK3) activity is repressed following insulin treatment of cells. Pharmacological inhibition of GSK3 mimics the effect of insulin on Phosphoenolpyruvate Carboxykinase (PEPCK), Glucose-6 Phosphatase (G6Pase) and IGF binding protein-1 (IGFBP1) gene expression. CAAT/enhancer binding protein alpha (C/EBP ) regulates these gene promoters in liver and is phosph...

Spotted scat ( Scatophagus argus ) is an important mariculture fish that of great economic significance in East and Southeast Asia. To date, there are no studies on ovary development regulation S. . Herein, the transcriptome profiles at different stages were constructed, genes pathways potentially involved secondary follicle growth identified. A total 25,426 detected by sequencing mRNAs from li...

Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously...

Introduction: The placenta expresses significant amounts of insulin and IGF1 receptors at distinct locations on both fetal maternal surfaces. This makes the receptor accessible to and/or insulin, IGF2. IGFs are involved in receptor-mediated regulation placental growth transport, angiogenesis. Maternal obesity during gestation mediates changes metabolism mothers, placentas as well growth. Object...

Antimicrobial (AM) resistance is largely acknowledged as one of the biggest global health and food safety challenges overuse AMs known to generate in bacteria that may affect both animals humans. Poultry meat second most-produced European Union recent years consumers are becoming more concerned about safety, traceability, animal welfare poultry rearing system, increasingly requiring meats from ...