objective: the prevalence of respiratory allergies, especially those induced by fungi such as alternaria alternata, has dramatically increased over the past decade. this increase has caused major health problems worldwide. this study aimed to investigate the role of a. alternata in the etiology of allergic asthma, by using the skin prick test and assessment of ige specific to the fungus in the ...

emerging data suggest that measurement of serum ige to peanut components can be clinically helpful and more accurate than ige to whole peanut to predict peanut allergy. not all studies have used prospective samples, multiple components and oral challenges. currently, there are no data on this topic involving italian children. 32 patients (23 males; median age 9 years) with reported history for ...

background: decay of vaccine–induced antibody titres without boosting of the wild measles virus has been well documented. revaccination against measles has reduced the prevalence of the disease worldwide. revaccination may cause ige induced anaphylaxis. objective: to study measles igg antibody in revaccinated populations and its relation to ige induced hypersensitivity. methods: blood samples w...

BACKGROUND Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to cell surface receptors such as FcepsilonRI and FcepsilonRII (CD23). The aim of this study was to analyze the relationships between levels of serum IgE, cell-bound IgE, and IgE-re...

hyper ige syndrome (hies) is a rare primary immunodeficiency disease. most of hies cases are sporadic. hies type ad is caused by mutation in signal transducer and activator of transcription-3 (stat-3). a number of mosaicism hies has been reported that is associated with intermediate phenotype. autosomal recessive hies (ar-hies) is due to mutation in dock-8 or cytokine sis 8 and tyk2 or tyrosine...

Food allergy is a significant public health problem with limited treatment options. As Allergy Herbal Formula 2 (FAHF-2) showed potential for food treatment, we further developed purified version named EBF2 and identified active compounds. We investigated the mechanisms of on IgE-mediated peanut (PN) its compound, berberine, IgE production.

BACKGROUND Sensitization to Anisakis spp. can produce allergic reactions after eating raw or undercooked parasitized fish. Specific IgE is detected long after the onset of symptoms, but the changes in specific IgE levels over a long follow-up period are unknown; furthermore, the influence of Anisakis spp. allergen exposure through consumption of fishery products is also unknown. OBJECTIVE To ...

We have investigated expression of an IgE-binding factor (IgE-BF) cDNA in both COS-7 monkey kidney cells and Chinese hamster ovary cells. Transient expression of the IgE-BF clone in either cell type yielded IgE-BF, which potentiated an in vitro IgE response and had an affinity for lentil lectin. In contrast, when the transient expression experiments were carried out in the presence of tunicamyc...