instance, is associated primarily with activation of S James M. Roberts Division of Basic Sciences phase whereas CDK1 primarily with mitosis. However, assays using defined peptides reveal only subtle differFred Hutchinson Cancer Research Center and Howard Hughes Medical Institute ences in substrate preference between CDK1 and CDK2 (Holmes and Solomon, 1996), and there is no compelling 1100 Fair...

This article presents an assessment of the power of ideas and their role in initiating change and progress. The enormous potential cascade effect is illustrated by examining the movement of Modernism in the arts. Next, the immense scope and capabilities of the modern scientific endeavor-with robotic space exploration at the scale of 10 meters at one extreme and the wonders of nanoscience at the...

WK E HAVE had to revamp many of our old ideas about feeding livestock. War proved again the tremendous importance of food. Wc had to get all the milk, eggs, poultry, meat, pork, lard, beef, veal, lamb, and mutton we could and make every tittle of grain count in doing so. Chicken was compared with hog and hog with steer to see which yielded the most nutrients for humans in return for the least f...

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To the Editor:—In a recent letter, Erickson and Lanier reported on a useful method to preoxygenate claustrophobic patients who will not tolerate a facemask, by having the patients hold the L-connector of the anesthesia circuit in their mouth. They may be interested to know that an identical method, complete with an almost identical photograph, was published as a correspondence by Keifer and Sti...

New Ideas In Pathfinding

The IDEAS design system is an innovative algorithm engineering environment. It can be employed to derive correct and e cient software or hardware implementations from algebraic speci cations using the advanced formal method ART. Several case studies for some algorithm engineering tasks are discussed in this article to demonstrate the feasibility of this system.

How ideas are passed from one person to another, or to a group of others, is a subject which is by no means so clear as would seem at first sight. It is of course obviously of prime importance in many walks of life, from the teacher to the politician; and (it is to be devoutly hoped) all concerned are prepared to study the subject scientifically. Less obvious, but equally vital, is the problem ...