The purpose was to analyse whether non-speech vocalisations in seizures originating in the frontal lobe do have lateralising value. Patients were included who had undergone presurgical evaluation with ictal video-EEG monitoring at the Epilepsy Centre, had had resective epilepsy surgery involving the frontal lobe, and who had remained seizure free>1 year postoperatively. Twenty seven patients ag...

Previous developmental studies in vitro suggested that the inhibitory neurotransmitter GABA exerts depolarizing and excitatory actions on the immature neurons and that depolarizing GABA is causally linked to ictal activity during the first weeks of postnatal life. However, remarkably little is known on the role of GABA in the generation of neonatal seizures in vivo. Here, using extracellular re...

Epileptic seizures can initiate a neural circuit and lead to aberrant neural communication with brain areas outside the epileptogenic region. We focus on interictal activity in focal temporal lobe epilepsy and evaluate functional connectivity (FC) differences that emerge as function of bilateral versus strictly unilateral epileptiform activity. We assess the strength of FC at rest between the i...

The present study was undertaken to investigate the effects of Zataria multiflora and Eucalyptus globolus essential oils on some haematological parameters and respiratory burst activity in common carp (Cyprinus carpio). 260 fish (30±5g) were randomly distributed in 13 treatment groups each one in three replicates and different doses of essential oils in 16-17ºC were administrated. The fish were...

Nonconvulsive status epilepticus (NCSE) can produce a wide spectrum of clinical symptoms depending on the regions and the relative amount of brain that is made dysfunctional by persistent epileptic discharges. NCSE can cause ictal behaviors resembling psychosis. However, only a few clear cases of NCSE causing diverse features of psychosis have been reported. We describe a patient with NCSE duri...

Tonic-clonic seizures represent a common pattern of epileptic discharges, yet the relationship between the various phases of the seizure remains obscure. Here we contrast propagation of the ictal wavefront with the propagation of individual discharges in the clonic phase of the event. In an in vitro model of tonic-clonic epilepsy, the afterdischarges (clonic phase) propagate with relative unifo...

PURPOSE Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in generation and spread of seizures in epilepsy patients. Because the spatial distribution and extent of ictal CBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a rat model of amygdala-kindled seizures to follow the time-dependent changes in the ...