The monitoring of trace metals in human urine plays an important role in research. Traditionally, urine analysis has been accomplished by graphite furnace atomic absorption (GFAA). However, when large numbers of samples are analyzed for multiple elements, GFAA becomes very cumbersome and restrictive, since it can only determine one element at a time. Additionally, the detection capability of IC...

A new matrix-matched reference material has been developed – NFHS-2-NP (NIOZ Foraminifera House Standard-2-Nano-Pellet) with element mass fractions, and isotope ratios resembling that of natural foraminiferal calcium carbonate. 180–355 µm size fraction planktic foraminifera was milled to nano-particles pressed pellets. We report information values for fractions forty-six elements measured by si...

Electrochemistry (EC) combined on-line with atomic mass spectrometry (MS) and related techniques (e.g., inductively coupled plasma atomic emission spectrometry, ICP–AES) affords an avenue for analysis of metals present at ultratrace levels and the effective elimination of matrix effects detrimental to atomic MS and spectrometric techniques. In addition, electrode reactions involving inorganic s...

INTRODUCTION Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the third trimester and associated with increased risks in fetal complications. Currently, the exact cause of this disease is unknown. In this study we aim to investigate the potential proteins in placenta, which may participate in the molecular mechanisms of ICP-related fetal complications using iTRAQ-based proteomics a...

The determination of iopromide in environmental waters has been accomplished using an Agilent 7700x ICP-MS coupled to an Agilent 1260 LC. The use of High Matrix Introduction (HMI) technology allows for prolonged operation with a sodium hydroxide (NaOH) eluent, and the Octopole Reaction System (ORS3) in helium gas mode reduces polyatomic interferences on iodine (m/z 127). Determination of ioprom...

Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder, mostly occurring in the third trimester. ICP is defined as an elevation of serum bile acids, typically accompanied by pruritus and elevated activities of liver aminotransferases. ICP is caused by impaired biliary lipid secretion, in which endogenous steroids may play a key role. Although ICP is benign for the pregnant woman...

We have developed a novel metal tag, bis(ethylenediamine)-4'-methyl-4-carboxybipyridine-ruthenium N-succinimidyl ester (ECRS) for sensitive analysis of amino acids using high performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICP-MS). ECRS is a functional reagent, containing an ester group at one end that can be activated to bind to amino group and a chelated r...