BACKGROUND Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy specific liver disease. However, the pathogenesis and etiology of ICP is poorly understood. AIM To assess the expression of peroxisome proliferator-activated receptorγ (PPARγ) and nuclear factor kappa B (NF-κB) in placenta and HTR-8/SVneo cell, and evaluate the serum levels of cytokines, bile acids, hepatic...

BACKGROUND The monitoring of intracranial pressure (ICP) has a crucial role in the surveillance of patients with brain injury. During long-term monitoring of ICP, we have seen spontaneous shifts in baseline pressure (ICP sensor zero point), which are of technical and not physiological origin. The aim of the present study was to explore whether or not baseline pressures of ICP sensors can be aff...

Intracranial pressure (ICP) measurement is an extremely important part of the neurosurgical armamentarium. Not only is raised ICP the commonest cause of death in neurosurgical patients, it is extremely common in patients suffering from head injury. In this latter group, 40% of patients who are admitted in an unconscious state have raised ICP, and in 50% of those who die, raised ICP is the main ...

OBJECTIVE To characterize the association between arterial blood pressure (ABP) and intracranial pressure (ICP) in idiopathic normal pressure hydrocephalus (iNPH) patients, and its impact on outcome of shunt surgery. MATERIALS AND METHODS We analyzed all 35 iNPH patients whose ABP and ICP were recorded simultaneously during 6 years (2002-2007). The static and pulsatile pressures were averaged...

Robust registration of two 3-D point sets is a common problem in computer vision. The Iterative Closest Point (ICP) algorithm is undoubtedly the most popular algorithm for solving this kind of problem. In this paper, we present the Picky ICP algorithm, which has been created by merging several extensions of the standard ICP algorithm, thus improving its robustness and computation time. Using pu...

Increased intracranial pressure (ICP) has an adverse effect on the clinical course of patients with severe head injuries. Direct intracranial measurement is the only method of knowing the precise ICP. At the Maryland Institute for Emergency Medical Services Systems, elevations in ICP are treated according to an aggressive protocol. Our experience with this protocol has led to the following conc...

Our understanding of what if any role intracranial pressure (ICP) plays in the manifestation of the optic neuropathy called glaucoma is only beginning to develop. ICP can have a profound effect on the optic nerve. Edema of the optic nerve head is of course an accepted consequence of elevations in ICP. Venous pulsations are seen in some individuals with normal or low ICP. Therefore some local al...

The performance of flexible fiberoptic bronchoscopy (FFB) has anecdotally been considered to carry a high risk of neurologic complications in patients with raised intracranial pressure (ICP). There is no evidence in the literature to support this concern. We evaluated this risk by reviewing hospital records of 132 patients who underwent FFB and computer tomography of the central nervous system ...

The current gold standard for the diagnosis of elevated intracranial pressure (ICP) remains invasive monitoring. Given that invasive monitoring is not always available or clinically feasible, there is growing interest in non-invasive methods of assessing ICP using diagnostic modalities such as ultrasound or magnetic resonance imaging (MRI). Increased ICP is transmitted through the cerebrospinal...

The Aurora B kinase complex is a critical regulator of chromosome segregation and cytokinesis. In Caenorhabditis elegans, AIR-2 (Aurora B) function requires ICP-1 (Incenp) and BIR-1 (Survivin). In various systems, Aurora B binds to orthologues of these proteins. Through genetic analysis, we have identified a new subunit of the Aurora B kinase complex, CSC-1. C. elegans embryos depleted of CSC-1...