BACKGROUND AND PURPOSE The purpose of this study was to investigate the effects of unequal physiologic flow conditions in the internal carotid arteries (ICAs) on the hemodynamics of anterior communicating artery aneurysms. METHODS Patient-specific computational fluid dynamics models of 2 cerebral aneurysms were constructed from bilateral 3D rotational angiograms. The flow dynamics of the aneu...

Diabetes and hypertension are potent risk factors for cerebrovascular disease. We studied the effects of an angiotensin II type 1 receptor blockade (ARB) on brain damage in hypertensives in relation to diabetes. We studied cerebral metabolism (by proton magnetic resonance spectroscopy) and hemodynamics (by phase-contrast magnetic resonance angiography) before and 3 to 4 months after candesartan...

Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adul...

Accurate semantic segmentation of each coronary artery using invasive angiography (ICA) is important for stenosis assessment and disease (CAD) diagnosis. In this paper, we propose a multi-step algorithm based on analyzing arterial segments extracted from ICAs. The proposed firstly extracts the entire binary mask (binary vascular tree) deep learning-based method. Then extract centerline tree sep...

BACKGROUND Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atheroscler...

Background and aims Hyperhomocysteinemia was recognized as a risk factor for cerebral infarction, especially caused by large-artery atherosclerosis (LAA). But whether high plasma total homocysteine (tHcy) is associated with cervico-cerebral atherosclerotic stenosis (CCAS) remains unclear. The aim of this study is to investigate whether elevated plasma tHcy is a risk factor for CCAS, and identif...

IMPORTANCE Intracranial arterial stenosis (ICAS) and small vessel disease (SVD) may coexist. There are limited data on the frequency and risk factors for coexistent SVD and the effect of SVD on stroke recurrence in patients receiving medical treatment for ICAS. OBJECTIVE To investigate the frequency and risk factors for SVD and the effect of SVD on stroke recurrence in patients with ICAS. D...

Cerebral small vessel disease (CSVD) commonly coexists with intracranial atherosclerotic stenosis (ICAS). Previous studies have tried to evaluate the relationship between ICAS and CSVD; however, they yielded varied conclusions. Furthermore, methodology of these is not very rigorous, as evaluated association CSVD bilateral hemispheres rather than affected hemisphere. Unilateral middle cerebral a...

OBJECTIVES The degree of preoperative cerebrovascular disease in patients undergoing cardiovascular surgery has not been well studied. Thus, the purpose of this study was to evaluate the prevalence and severity of cerebrovascular disease in such patients. METHODS The subjects were 91 patients who underwent cardiovascular surgery. We investigated the prevalence and severity of cerebral infarct...

Intracranial arterial stenosis (ICAS) is an important cause of ischemic stroke and transient ischemic attack (TIA), and the correlation between the plasma non-high density cholesterol (non-HDLC) levels and ICAS, especially asymptomatic ICAS (AICAS) is not clear. The Asymptomatic Polyvascular Abnormalities Community(APAC) study is a community-based, prospective, long-term follow-up observational...