نتایج جستجو برای: icam

تعداد نتایج: 6532  

2010
Jaap D. van Buul Jos van Rijssel Floris P. J. van Alphen Anna-Marieke van Stalborch Erik P. J. Mul Peter L. Hordijk

In the initial stages of transendothelial migration, leukocytes use the endothelial integrin ligands ICAM-1 and VCAM-1 for strong adhesion. Upon adhesion of the leukocyte to endothelial ICAM-1, ICAM-1 is clustered and recruited to the adhered leukocyte, promoting strong adhesion. In this study, we provide evidence for the colocalization of VCAM-1 at sites of ICAM-1 clustering. Anti-ICAM-1 antib...

2017
David Núñez Laura Comas Pilar M. Lanuza Diego Sánchez-Martinez Marta Pérez-Hernández Elena Catalán María Pilar Domingo Adrián Velázquez-Campoy Julián Pardo Eva M. Gálvez

The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for the regulation of several physiological and pathophysiological processes like cell-mediated elimination of tumor or virus infected cells, cancer metastasis, or inflammatory and autoimmune processes. Using purified proteins it was reported a species rest...

Journal: :Investigative ophthalmology & visual science 2003
Akiko Nishiwaki Takashi Ueda Shinya Ugawa Shoichi Shimada Yuichiro Ogura

PURPOSE Vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules, after retinal ischemia. They mediate the transmigration process of leukocytes. For further understanding of the role of leukocytes after retinal ischemia-reperfusion injury, the responses of the leukocyte-endothelial cell adhesion molecules P-selectin...

Journal: :The Journal of Cell Biology 2007
Li Tian Michael Stefanidakis Lin Ning Philippe Van Lint Henrietta Nyman-Huttunen Claude Libert Shigeyoshi Itohara Masayoshi Mishina Heikki Rauvala Carl G. Gahmberg

Matrix metalloproteinase (MMP)-2 and -9 are pivotal in remodeling many tissues. However, their functions and candidate substrates for brain development are poorly characterized. Intercellular adhesion molecule-5 (ICAM-5; Telencephalin) is a neuronal adhesion molecule that regulates dendritic elongation and spine maturation. We find that ICAM-5 is cleaved from hippocampal neurons when the cells ...

Journal: :The American journal of physiology 1997
Mariette L Yu Andrew H Limper

Inflammatory cell recruitment contributes to respiratory impairment during Pneumocystis carinii pneumonia. We evaluated expression of intercellular adhesion molecule-1 (ICAM-1), a key participant in leukocyte accumulation, in rats with P. carinii pneumonia. Immunostaining for ICAM-1 was most marked on bronchiolar epithelium but was also evident on type II pneumocytes, endothelium, and macrophag...

Journal: :The Journal of Cell Biology 1994
R C Landis A McDowall C L Holness A J Littler D L Simmons N Hogg

To analyze the binding requirements of LFA-1 for its two most homologous ligands, ICAM-1 and ICAM-3, we compared the effects of various LFA-1 activation regimes and a panel of anti-LFA-1 mAbs in T cell binding assays to ICAM-1 or ICAM-3 coated on plastic. These studies demonstrated that T cell binding to ICAM-3 was inducible both from the exterior of the cell by Mn2+ and from the interior by an...

Journal: :The Journal of biological chemistry 1991
M Y Chiang H Chan M A Zounes S M Freier W F Lima C F Bennett

Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein expressed on the surface of both hemopoietic and nonhemopoietic cells that mediates, in part, the emigration of leukocytes out of the vasculature. Expression of ICAM-1 on the surface of human umbilical vein endothelial cells and a human lung carcinoma cell line (A549) was increased by interleukin-1 beta, tumor necrosis factor alpha, a...

2001
Patrick J. Pagano Mahmoud Tayeh Nour-Eddine Rhaleb Arash Kiarash Oscar A. Carretero

Intercellular adhesion molecule-1 (ICAM-1), part of an immunoglobulin-like superfamily of adhesion molecules, is involved in several cardiovascular diseases. We investigated whether in vivo angiotensin II (Ang II) increases ICAM-1 in rats. Sprague-Dawley rats were infused with vehicle or Ang II (750 mg z kg z d SC) for 7 days. The contribution of Ang II receptors to ICAM-1 expression was invest...

Journal: :Hypertension 2001
Arash Kiarash Patrick J. Pagano Mahmoud Tayeh Nour-Eddine Rhaleb Oscar A. Carretero

-Intercellular adhesion molecule-1 (ICAM-1), part of an immunoglobulin-like superfamily of adhesion molecules, is involved in several cardiovascular diseases. We investigated whether in vivo angiotensin II (Ang II) increases ICAM-1 in rats. Sprague-Dawley rats were infused with vehicle or Ang II (750 µg. kg(-1). d(-1) SC) for 7 days. The contribution of Ang II receptors to ICAM-1 expression was...

Journal: :Infection and immunity 1996
M Verdrengh T A Springer J C Gutierrez-Ramos A Tarkowski

Intercellular adhesion molecule 1 (ICAM-1) is a member of the immunoglobulin superfamily that interacts with two integrins, LFA-1 and Mac-1. These interactions are critical for leukocyte extravasation into inflamed tissue. To assess the role of ICAM-1 expression in the pathogenesis of bacterial infection, homozygously mutant mice lacking the ICAM-1 gene were exposed to Staphylococcus aureus. Wi...

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