impact on Ibn Tufayl's forerunners, especially Avicenna, whom Ibn Tufayl quotes expressly. Salim Kemal's 'Justifications of poetic validity' gives a very condensed summary of his monograph The poetics ofAlfarabi and Avicenna (Leiden, 1991). But I doubt whether Ibn Tufayl's novel kind of thought experiment can be grasped in terms of Avicenna's poetology. The medieval Latin translators did not co...

PURPOSE Because of rising drug expenditures, cost considerations have become essential, necessitating the requirement for cost-effectiveness analyses for managed care organizations (MCOs). The study objective is to examine the impact of various drug-cost components, in addition to wholesale acquisition cost (WAC), on the cost-effectiveness of osteoporosis therapies. DESIGN A Markov model of o...

Laboratoire de Biologie et Santé, Unité de recherche Associée au CNRST-URAC 34, Faculté des Sciences Ben M'Sik, Université Hassan II Mohammedia, Casablanca, Maroc, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculté de Médecine et Pharmacie, Université Hassan II, Casablanca, Maroc, Département de Pédiatrie 1, Hôpital d'Enfants de Rabat, CHU Ibn Sina, Rabat, Maroc, Département ...

This is a study and translation of the section on pericarditis in Al Taisir book written by the Muslim physician Ibn Zuhr Avenzoar who lived and practiced in Eshbeelia nowadays Seville, Andalusia, Spain between 1091-1162 AD. Ibn Zuhr described the serous type of pericarditis as well as the pathological findings in fibrinous pericarditis. His description of the latter may also fit with the pictu...

INTRODUCTION Osteoporosis usually affects post-menopausal women. Treatment is individualized and requires an approach that will provide long-term compliance to prevent fractures. Studies conducted so far suggest inadequate compliance and persistence in weekly bisphosphonate treatment (under 43% after a year of treatment). Ibandronate, as a powerful bisphosphonate, has made it possible for the f...

Multiple steps are involved in the metastasis of cancer cells from primary sites to distant organs. These steps should be considered in the design of pharmacologic approaches to prevent or inhibit the metastatic process. In the present study, we have compared the effects of inhibiting several steps involved in the bone metastatic process individually with inhibition of both together. The steps ...

Locus PA4043 in the genome of Pseudomonas aeruginosa PAO1 has been annotated as coding for a farnesyl pyrophosphate synthase (FPPS). This open reading frame was cloned and expressed recombinantly in Escherichia coli. The dimeric enzyme shows farnesyl pyrophosphate synthase activity and is strongly inhibited by ibandronate and zoledronate, drugs that are presently in clinical use. The structures...

This work is the latest product of Albert Dietrich's investigations into the transmission and expansion of the Materia medica of Dioscorides in the medieval Islamic world; here he publishes, with German translation and commentary, a text by the renowned Andalusian physician Ibn Juljul (d. c. 384/994) describing 62 items not mentioned by Dioscorides. Such works were important contributions to th...

OBJECTIVE CURRENT, a large, open-label, 6-month, multicenter study, was designed to assess patient satisfaction levels and patient treatment preference after switching from weekly oral bisphosphonates to monthly oral ibandronate for a period of 6 months. METHODS This study enrolled postmenopausal women who had taken a weekly oral bisphosphonate for at least 3 months for prevention or treatmen...

The purpose of presenting review was to share the medicinal and surgical contribution of Greco-Arabic Muslim scientists in diagnosis, surgery and natural medicines for the management and treatment of urolithiasis. The contribution of Al-Antaki, Al-Baghdadi, Al-Baitar, Al-Bokhari, Al-Razi, Al-Zahrawi, Ibn Sina, Ibn Zuhr was highlighted. The data compilation was preliminary and much more efforts ...