BACKGROUND Glutamate has been implicated in the pathophysiology of acute hypoxic-ischemic encephalopathy. Glutamine synthetase is an enzyme found in astrocytes that converts glutamate to its nontoxic analogue, glutamine. The present study tests the hypothesis that brain glutamine synthetase activity increases in response to acute hypoxic-ischemic insults and not in response to chronic hypoxia-i...

Hypoxic-ischemic cerebral injury that occurs during the perinatal period is one of the most commonly recognized causes of severe, long-term neurologic deficits in children; it is often referred to as cerebral palsy. Despite improvements in perinatal practice during the past several decades, the incidence of cerebral palsy attributed to intrapartum asphyxia has remained essentially unchanged, pr...

Aims Hypoxic-ischemic injury (HI) to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term borns with hypoxic-ischemic encephalopathy, saving one in eight infants from developing severe neurological deficits. Therefore, additional treatments with clinically applicable drugs are indispensable. Furthermo...

The need for mastering the complexity of software systems and the hereby related demands for maintenance and changeability is partly fulfilled by the principles and benefits of objectorientation. The basic idea behind object-orientation is to reflect the real world into the physical software model one is trying to develop. Although these ideas were introduced a long time ago in the educational ...

Oguzhan Karatepe1*, Idris Kurtulus1, Orcun Unal1, Orhan Yalcin1, Ahu Kemik2, Gulcin Kamali3, Gokhan Adas1, Muharrem Battal1, Mine Adas1, Hale Ozgun4 and Murat Aksoy5 1Okmeydani Training and Research Hospital, Department of Surgery 2Istanbul Faculty of Medicine, Department of Biochemistry Okmeydani 3Training and Research Hospital, Department of Pathology 4Istanbul Technical University, Departmen...