Immunohistochemistry is very useful when investigating the cause of death. Ischemic cell changes in the hippocampal neurons were not obvious in the brains damaged by hypoxic injury. However, it is suggested that even a moderate hypoxia, which may affect the neuronal proteins and metabolism, induced astrocytosis in the CA3 and CA4 regions, and that in patients with a history of hypoxic attacks n...

We report a case of fatal methaemoglobinaema resulting from sodium nitrite poisoning. A 28 year old woman arrested in the emergency department following collapse. During resuscitation venous blood gas revealed methaemoglobin percentage 81%. Following treatment with methylene blue, bicarbonate and adrenaline, decreased. Prior to transfer intensive care, CT head extensive hypoxic brain injury. Tw...

Perinatal hypoxic ischemia (H-I) causes brain damage and long-term neurological impairments, leading to motor dysfunctions and cerebral palsy. Many studies have demonstrated that the TrkB-ERK1/2 signaling pathway plays a key role in mediating the protective effect of brain-derived neurotrophic factor (BDNF) following perinatal H-I brain injury in experimental animals. In the present study, we e...

Neonatal hypoxic-ischemic(H/I) brain damage is a serious complication of intrauterine asphyxia during perinatal period, eventually leading to severe long-term neurodevelopmental disability or even death. Survival babies would experience cerebral palsy, epilepsy, mental retardation, cognitive, sensory and motor dysfunctions. However, there has no proven effective treatment available to protect t...

OBJECTIVE This study aimed to correlate amplitude-integrated electroencephalography findings with early outcomes, measured by mortality and neuroimaging findings, in a prospective cohort of infants at high risk for brain injury in this center in Brazil. METHODS This blinded prospective cohort study evaluated 23 preterm infants below 31 weeks of gestational age and 17 infants diagnosed with hy...

Purpose: To investigate the effect of asiatic acid on hypoxic ischemia-induced injury in neonatal rats, and underlying mechanism action.Methods: Hypoxic-ischemia (HI) rat model was established via permanent ligation carotid artery, followed by hypoxia (exposure to 8 % oxygen 92 nitrogen) for 24 h. Immunofluorescence, using fluorescence microscope, used determination expressions p-TAK1, NeuN GFA...

Objectives This study aimed to identify differences in absolute neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio between neonates with two forms of ischemic brain injury, hypoxic-ischemic encephalopathy, and acute ischemic stroke, compared to controls. We also aimed to determine whether this neutrophil/lymphocyte response pattern is associated with disease severity or is a consequen...