Background Many patients with pulmonary arterial or chronic thromboembolic hypertension (PH) wish to travel altitude by airplane, but their risk of hypoxia-related adverse health effects is insufficiently explored. Research Question How does hypoxia, compared normoxia, affect constant work-rate exercise test (CWRET) time in PH, and which physiologic mechanisms are involved? <h...

Hypoxia is defined as any combination of reduced barometric pressure (PB) and/or a reduced inspired fraction of oxygen (FIO2), which ultimately results in an inspired partial pressure of oxygen (PIO2) less than 150 mmHg (6). Pathophysiological responses to hypoxia or adaptations to hypoxic training can be investigated in two different types of exposure: hypobaric hypoxia (HH; FIO2 20.9%; PB 760...

the purpose of present research was to investigate the effect of high-intensity interval exercise (hie) in hypoxia and normoxia conduction on response of serum vegf in inactive men. to this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (w max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects....

Heat acclimation (HA) attenuates physiological strain in hot conditions via phenotypic and cellular adaptation. The aim of this study was to determine whether HA reduced physiological strain, and heat shock protein (HSP) 72 and HSP90α mRNA responses in acute normobaric hypoxia. Sixteen male participants completed ten 90-min sessions of isothermic HA (40°C/40% relative humidity) or exercise trai...

Physiological responses to hypoxia in children are incompletely understood. We aimed to characterize cerebrovascular and ventilatory responses to normobaric hypoxia in girls and women. Ten healthy girls (9.9 ± 1.7 years; mean ± SD; Tanner stage 1 and 2) and their mothers (43.9 ± 3.5 years) participated. Internal carotid (ICA) and vertebral artery (VA) velocity, diameter and flow (Duplex ultraso...

The physiological responses to apnea training exhibited by elite breath-hold divers may contribute to improving sports performance. Breath-hold divers have shown reduced blood acidosis, oxidative stress and basal metabolic rate, and increased hematocrit, erythropoietin concentration, hemoglobin mass and lung volumes. We hypothesise that these adaptations contributed to long apnea durations and ...