Introduction. Explosive explosive injuries account for more than 50% of all received in military battles, and the proportion casualties among civilian population is also increasing [1]. However, only limited research has been conducted on pathophysiology blast-induced brain injury, effect changes cerebral blood flow (CBF) or vascular reactivity injury not investigated [2]. Although secondary hy...

Abstract Photodynamic therapy (PDT) is an emerging technology for tumor treatment in which photosensitizer (PS)-mediated light irradiation reduces oxygen, producing high levels of reactive oxygen species (ROS) that can cause vascular injury and effectively kill cells. However, the naturally hypoxic microenvironment main obstacle hinders photodynamic response vivo prevents its extensive applicat...

Background: Intracranial hypertension (IH) is a secondary clinical condition due to the loss of brain compensatory mechanisms, leading increased intracranial pressure (ICP) and changes in cerebral blood flow, which can result hypoxia, injury, herniation. Brain4care (b4c) device that explores variations compliance allows measurement ICP non-invasive serial way, addition, it predict evolution tre...

Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protective window after hypoxic preconditioning. The rats were preconditioned with hypoxia (8% oxygen, ...

CONTEXT Exposure of hepatocytes to pathological conditions in a microenvironment of hypoxia and reoxygenation is very frequent in hepatic diseases. Several substances present perspectives for cytoprotective action on hepatocyte submitted to reoxygenation after hypoxia and simple hypoxia. OBJECTIVE We research therapeutic options for hepatocytes submitted to hypoxia and hypoxia + reoxygenation...

macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...

PURPOSE Subglottic stenosis can result from endotracheal tube injury. The mechanism by which this occurs, however, is not well understood. The purpose of this study was to examine the role of angiogenesis, hypoxia and ischemia in subglottic mucosal injury following endotracheal intubation. METHODS Six Yorkshire piglets were randomized to either a control group (N=3, ventilated through larynge...

Intestinal epithelial cells (IEC) act as an important intestinal barrier whose function can be impaired upon induction by hypoxia. Although injuries are preventable milk-derived exosomal microRNAs (miRNAs), the underlying mechanism remains poorly understood. This study aimed to characterize effect of yak and cow milk–derived miRNA on IEC-6 under hypoxic conditions, explore milk relieve hypoxia ...

Chronic intermitted hypoxia including sleep breathing disorder leads to brain injury. This study explores the potential therapeutic effects of grape seed proanthocyanidin as a neuroprotective agent. A rat model of chronic intermittent hypoxia was employed, and the animals were given low or high doses of grape seed proanthocyanidin. The ultrastructure changes in the brain, the biochemical compon...

During the past several years much new evidence has accumulated regarding the molecular and biochemical mechanisms underlying cardiac responses to hypoxia and to ischemia/reperfusion injury. Studies have involved cell culture, and ex vivo and in vivo preparations. This review focuses on regulation of two transcription factors that are thought to be important in these processes, hypoxia-inducibl...