Abstract Background Tumor protein D52 (TPD52) reportedly plays an important role in the proliferation and metastasis of various cancer cells, including oral squamous cell carcinoma (OSCC) is expressed strongly at center tumor, where microenvironment hypoxic. Thus, present study investigated roles TPD52 survival death OSCC cells under hypoxia, relationship with hypoxia-inducible factor (HIF). We...

Abstract Glioblastoma (GBM) is a malignant brain tumor with poor prognosis that easily recurs. The antiangiogenic agent bevacizumab used to treat recurrent GBM. However, GBM treated rebounds due evasive mechanisms induce resistance treatment, such as hypoxia‐inducible factor (HIF) associated pathways. transcription HIFs are oxygen‐dependent and degraded via the ubiquitin‐dependent proteasomal p...

Hypoxic stress, caused by the low cellular oxygen in events of flooding or waterlogging, limits crop productivity many regions world. stress plants is often dynamic and followed a reoxygenation process that returns level to normal. Although metabolic responses hypoxia have been studied plants, less known about recovery processes following removal. To better understand shift from low-oxygen envi...

Hypoxia is one of the most important environmental stressors in aquatic ecosystems. To deal with hypoxia environment, fishes exhibit a series physiological and molecular responses to maintain homeostasis organism functions. In present study, hypoxia-induced changes gene expression profiles alternative splicing (AS) events spotted sea bass ( Lateolabrax maculatus ), promising marine-culture fish...

Hypoxia-sensitive peripheral carotid chemoreceptors, which regulate sympathetic outflow from the brain stem, are promising antihypertensive treatment targets. However, central nervous pathways integrating human chemoreflexes poorly understood. We combined high-resolution functional magnetic resonance imaging with physiological profiling to elucidate hypothalamic and medullary responses acute hy...

the purpose of present research was to investigate the effect of high-intensity interval exercise (hie) in hypoxia and normoxia conduction on response of serum vegf in inactive men. to this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (w max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects....

Background: Mesenchymal stem cells (MSCs) are important candidates for MSC-based cellular therapy. Current paradigm states that MSCs support local progenitor cells in damaged tissue through paracrine signaling. Therefore, study of paracrine effects and secretome of MSCs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. This study ...

Silent hypoxia is a well-known entity associated with SARSCoV-2 [1,2]. It condition where despite the patient being hypoxic, they do not show any signs and symptoms of respiratory distress [2]. Hypoxia can only be detected either by pulse oximetry reading or through blood gas analysis. These patients may have variable radiological appearances on presentation. Many studies shown silent has high ...

Abstract Background Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule ? (RELM-?) is upregulated de novo response to hypoxia cultured human PASMCs (hPASMCs). RELM-? has been reported promote hPASMC and involved vascular remodeling patients with PAH. However, the...