A protein kinase domain, a Rhodanase-like and the Tre-2/Bub2/Cdc16 (TBC) domain are all encoded by TBCK gene. By modulating mammalian target of rapamycin (mTOR) signaling pathway, is hypothesized to play role in actin organization, cell growth, proliferation. Has organization cytoskeleton.

To analyze the relationship between arginine and blood ammonia, nutritional status, immunity, and to explore the regulating function of arginine in cerebral palsy infants with muscle hypotonia. We chose 96 cases with muscle hypotonia cerebral palsy from January 2009 to January 2012 in rehabilitation center of Zhengzhou children hospital as the research object, using the questionnaire survey to ...

objective prader-willi syndrome (pws) is a genetic syndrome presenting with severe hypotonia and decreased agility. growth hormone (gh), which is often used in these patients to treat short stature and obesity, seems improve hypotonia, physical strength, activity, and locomotor developmental ability. the aim of this study was to find the effects of growth hormone on agility and strength of thes...

Case presentation: 5-year-old girl, born from a consanguineous couple, is referred to our service due weakness and hypotonia. It was necessary hospitalization, after birth, respiratory insufficiency severe motor delay already evident in the first months of life. At 6 she did not have head control at 12 able sit without support. She developed problems with apneas hypercapnia, 3 years age, that t...

BACKGROUND Clinical assessment of hypotonia is challenging due to the subjective nature of the initial clinical evaluation. This poses dilemmas for practitioners in gaining accuracy, given that the presentation of hypotonia can be either a non-threatening or malevolent sign. The research question posed was how clinical assessment can be improved, given the current contentions expressed in the s...