Isolated maternal hypothyroxinemia (IMH) during pregnancy is defined as a low maternal T4 in the absence of TSH elevation. As IMH is common, with a prevalence of 1-2% in iodine-sufficient populations, and early research has suggested adverse effects on fetal neurodevelopment, it has been the focus of many studies in the last decade. In the current review, we first discuss the significance of IM...

Rapid advances in neonatal care have led to a dramatic surge in survival of the veryand extremely-premature infants. This is, however ,tempered by a concomitant increase in the incidence of severe neuromorbidity in the survivors, including cognitive delay, cerebral palsy, hearing loss, blindness, mental retardation, and epilepsy. Thus, an emerging challenge in newborn care is to translate the g...

The article by Pere Berbel and his Spanish coworkers, published in this issue of Thyroid (1), is fascinating both for the results reported and its clever study design, unique among all other studies published so far on the consequences of iodine deficiency (ID) during pregnancy. Because this study combines data on specific maternal aspects with information on infant neurodevelopment, the presen...

Thyroid hormones play an important role during pregnancy, providing organogenesis, growth and development of the fetus, teach in formation brain its structure, influencing cognitive abilities. dysfunction is associated with pathological course pregnancy childbirth, as well a negative effect on fetus. Iodine deficiency, which persists throughout Uzbekistan, creates prerequisites for more frequen...