1. This noradrenaline-induced accumulation of cyclic AMP is decreased in both the anterior and the posterior hypothalamus of hypertension-prone as compared with resistant rats, but is similar in the cortex. 2. The noradrenaline-induced accumulation of cyclic AMP is decreased in the posterior hypothalamus as compared with the anterior hypothalamus of both strains. 3. The decreased sensitivity to...

Acetylcholinesterase (AChE), Na+,K(+)-ATPase and Mg(2+)-ATPase activities were estimated in homogenised rat pituitary and hypothalamus of 4- and 22-month-old rats. AChE activity was not altered in the pituitary of aged compared to adult rats, while it was found decreased by about 40% in the hypothalamus. Na+,K(+)-ATPase activity remained stable in the hypothalamus, while it was decreased by abo...

Background: Pituitary Radiological study is important to evaluate hypothalamus/hypophisis axis problems. There are studies that describe correlation between pituitary radiological abnormalities and hipopituitarism at general population, but few neuroradiological after traumatic brain injury in pediatric and, when they do, it´s only isolated case reports.

Leptin is a circulating molecule for the regulation of food intake and body weight suggested to be mediated in the hypothalamus via Ob-Rb receptor, which activates Janus kinase-signal transducer and activator of transcription (STAT) pathways. Although leptin receptors exist in many regions of the brain, there have been few in vivo functional studies of leptin's target site other than the hypoth...

The fetal genome regulates maternal physiology and behavior via its placenta, which produces hormones that act on the maternal hypothalamus. At the same time, the fetus itself develops a hypothalamus. In this study we show that many of the genes that regulate placental development also regulate the developing hypothalamus, and in mouse the coexpression of these genes is particularly high on emb...

Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood-brain barrier has been reported leaky. A leaky blood-brain barrier implies high tissue glucose levels and obviates a role for endothelial glucose transporters in the control of hypothalamic glucose concentration, important in understanding the mechanisms of glucose sensi...

TRF(Thyrotrophin-Releasing-Factor) is produced in the anterior hypothalamus, deposited in the neurohypophysis, and then passed into the cerebrospinal fluid and the blood stream to be excreted into urine(Shibusawa et al., 1959c). It has been demonstrated neither in the median and posterior hypothalamus, nor in other tissues, and body fluids. It is an hitherto unknown hormone which controls the t...

Recent tremendous advances in our understanding of the regulation of food intake are expected to contribute to the treatment of obesity in the near future. The hypothalamus is a center for regulation of food intake and NPY/AgRP and POMC neurons are key regulators of food intake in the arcuate nucleus. The level of energy in the body is monitored by energy sensors in the hypothalamus. A variety ...