Background: Identification of tissue hypoxia and hypoperfusion plays an important role in the management critically ill patients. Although venous-arterial PCO2 difference (ΔPCO2) cannot serve...

Sepsis is associated with cardiovascular changes that may lead to development of tissue hypoperfusion. Early recognition of sepsis and tissue hypoperfusion is critical to implement appropriate hemodynamic support and prevent irreversible organ damage. End points for resuscitation need to be defined and invasive hemodynamic monitoring is usually required. Targets for hemodynamic optimization sho...

AUTOREGULATION is defined as the capacity of an organ or tissue to maintain a constant blood flow in the face of a change in perfusion pressure, while metabolism is unchanged. Under normal physiological conditions, large proximal arteries contribute little to the total resistance of a particular vascular bed. However, when atherosclerosis causes a conductance artery to narrow so that over 70% o...

BACKGROUND Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cbl status, functional imaging reports are limited. We herein retrospectively review the correlation of Tc-99 m ethyl cysteinate dimer single-photon emission computed tomography (...

Background The relation between hypoperfusion and fibrosis is not completely understood in hypertrophic cardiomyopathy (HCM). One hypothesis is that hypoperfusion is a primary cause of fibrosis. Therefore, the aim of this study was to use cardiac magnetic resonance (CMR) to 1) measure if regional perfusion is decreased in young patients with HCM and in subjects at risk of HCM compared to normal...

The beach-chair position in shoulder surgery provides advantages to the surgeon and anesthesiologist. However, cautious interpretation of the patient's blood pressure is essential, especially when the blood pressure cuff is placed at the calf. The calf pressure should be interpreted relative to the heart-level pressure to avoid iatrogenic cerebral hypoperfusion related to hypotensive anesthesia...

Sepsis is a very frequent condition and causes high mortality rates and healthcare costs; it is the main cause of death in intensive care units. Clear, improved prognosis was shown for early diagnosed and treated patients. Treatment guidelines are fundamental for appropriate therapy. It is clear that hypoperfusion patients should be hemodynamically optimized; therefore, recognition of hypoperfu...

BACKGROUND AND PURPOSE Insular cortex ischemia is proposed to mediate a sympathetic stimulus that leads to acute hyperglycemia after stroke. METHODS We retrospectively analyzed insular perfusion on perfusion CT (median 180 minutes after onset) in 35 patients. RESULTS We found no association of hypoperfusion (relative cerebral blood flow <0.51) with early (<6 hours) or delayed (<72 hours) hy...