Objective: Serum CXCL10 (an interferon-g-inducible chemokine) levels (sCXCL10) are increased in several autoimmune conditions, including Graves’ disease (GD) and autoimmune thyroiditis (AT). Longitudinal assessment of sCXCL10 in autoimmune hypoor hyperthyroidism has not yet been performed. Design and methods: We longitudinally assayed sCXCL10 in the following groups: 1. thirty-three GD and 11 t...

The influence of hypo-osmotic cell swelling on the activity of the mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 (where Erk stands for extracellular signal-regulated protein kinase) was studied in cultured rat astrocytes. Hypo-osmotic treatment led within 10 min to an increased activity of Erk-1 and Erk-2, which became maximal at 20 min and returned to the basal level within 60 min. M...

the variations of glucose 6-phosphate dehydrogenase (g6pd) activity in different brain regions of normal, hypo- and hyperthyroid rats were investigated. hypo- and hyperthyrodism were experimentaly induced by administration of methimazol and liothyronine, respectively. in normal rats, midbrain had the minimum (70 mu/mg) and cerebral cortex the maximum (349 mu/mg) g6pd activity. hyperthyrodism in...

In this paper we examine the use of hypotheticals as a heuristic device to assist a case-based reasoner test the strengths, weaknesses, and ramifications of an analysis or argument by exploring and augmenting the space of known cases and indirectly, the at tendant spaces of doctrine and argument. Our program, HYPO, works in the task domain of the law, particularly, the area of trade secret prot...

he proportion of survival of out-of-hospital cardiac arrest is improving with increased implementation of prompt bystander cardiopulmonary resuscitation (CPR) and early defibrillation; however, the neurologically intact survival for patients of out-of-hospital cardiac arrest still remains low worldwide. Furthermore, development of support measures such as pharmacological circulatory support for...

OBJECTIVES The aim of this study was to establish a new, dynamic 3-dimensional cardiac magnetic resonance (3D-CMR) perfusion scan technique exploiting data correlation in k-space and time with sensitivity-encoding and to determine its value for the detection of coronary artery disease (CAD) and volumetry of myocardial hypoenhancement (VOLUME(hypo)) before and after percutaneous coronary stentin...

We investigated the effect of thyroid hormone status on renal handing of Ca2+. Further, like kinetics of Ca2+ transport across brush-border membrane (BBM) and basolateral membrane (BLM) of renal epithelial cells was carried out. FE(Ca) was decreased in hyperthyroid (Hyper-T) rats and increased in hypothyroid (Hypo-T) rats as compared to euthyroid (Eu-T) rats. Ca2+ uptake into renal brush-border...

Despite the tremendous development in CNC programming facilities, linear and circular cuts parallel to the coordinate planes continue to be the standard motions of modern CNC machines. However, the increasing industrial demand for parts with intricate shapes cannot be satisfied with only these standard motions. The proportion of parts which are not covered by the standard CNC motions is certain...