BACKGROUND Colorectal adenomatous and, probably, hyperplastic polyp development requires epithelial remodelling and stratification, with loss of E-cadherin expression implicated in adenoma formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with colitis. AIMS (i) To investiga...

The course of acalculous adenomyomatosis of the gallbladder in six patients is described. It is suggested that, even in the absence of gallstones, cholecystectomy should be advised when this condition is demonstrated radiographically in symptomatic subjects. The cause of the pain is unknown but it is probably related to excessive neuromuscular activity of the hyperplastic gallbladder wall. One ...

Inflammation is a hallmark of colorectal cancer (CRC). Neutrophils are well-known mediators in tumor biology but their role in solid tumors, including CRC, was redefined by neutrophil extracellular traps (NETs). Given that it was recently demonstrated that platelet-derived polyP primes neutrophils to release NETs, we examined surgical specimens from CRC to investigate the presence of polyP, as ...

Rhinosporidiosis is an inflammatory disease caused by Rhinosporidium seeberi, a protoctistan mesomycetozoa, member of a group of novel aquatic parasites, characterized by hyperplastic polypoid lesions of the nasal cavity and rarely other mucous membranes. We report an unusual presentation of rhinosporidiosis as an urethral polyp, which is only the second case of rhinosporidiosis reported from P...

Aim : to analyze the safety and effectiveness of method cold snaring resection with preliminary hydropreparation when removing superficially colorectal epithelial neoplasms a diameter 5 25 mm. Material methods . The number complications disease recurrence after endoscopic excisions by “cold” mm was assessed. Results Neoplasms were removed in single block 89/122 (72.95 %) cases. 9 100 % cases, 1...

Aim : to analyze the safety and effectiveness of method cold snaring resection with preliminary hydropreparation when removing superficially colorectal epithelial neoplasms a diameter 5 25 mm. Material methods . The number complications disease recurrence after endoscopic excisions by “cold” mm was assessed. Results Neoplasms were removed in single block 89/122 (72.95 %) cases. 9 100 % cases, 1...

Two isoforms of prostaglandin H synthase (PTGS = COX) are key enzymes in prostaglandin synthesis and primary targets for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). Use of aspirin or other NSAIDs is associated with a lower risk and reduced recurrence of colorectal adenomas, established precursors of adenocarcinoma. This study investigated risk of colorectal adenomatous and...

Endotoxins are known to be associated with the occurrence of various chronic diseases. This study was conducted to investigate the role of endotoxins in the pathogenesis of colon polyps through a case-control study. A total of 145 subjects (74 subjects in the polyp group and 71 subjects in the control group) had undergone a colonoscopy. Age, body mass index (BMI) and endotoxin levels were found...